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Mass spectrometry molecular separation via mass/charge (m/z) ratios. Each of the various ionization approaches excels in targeting different molecule types. Understanding these techniques can help you pick the optimal ionization method to “make your molecules fly” and reveal their unique mass spectra. Read this article to learn more.
This article explains a simple, 4-step method for automatic cell counting with ImageJ. Perfect for your cell proliferation studies, gene expression analysis, or whatever your downstream application might be.
Tissue processing for histology is a key step between fixation and embedding. We take you through the steps of tissue processing in this simple guide.
Adherent cell fixation is a crucial step in preparing cells for microscopy and imaging, ensuring that cellular structures are preserved for detailed analysis. Read our 8-step guide on how to effectively fix adherent cells to your microscope slides, including tips on sterilization, coating, and fixation methods, right here.
Ever wondered what magic happens to turn your samples into histology slides? Find out the 5 simple steps for histology slide preparation.
The emergence of Volume Electron Microscopy (vEM) has unlocked new possibilities in biological imaging, enabling us to visualize 3D structures of cells at high resolution. Learn more about this incredible technique in our latest article.
Discover what hematoxylin and eosin staining is used for and how it works, in this concise guide.
Do you prepare samples for electron microscopy and want to save time, money, effort, and frustration? This article provides hands-on advice to help you get the best possible data out of your EM experiments.
Learn how confocal laser scanning microscopy works, its applications, and why it’s great for samples that are too thin to section.
Having problems with your in situ hybridization? We’ve got 7 simple tips to help you get outstanding results.
Achieving publication-quality immunofluorescence images is tricky. Learn what controls for immunofluorescence you can use to get them!
Digital images are essential to communicate your data. Get the information and tools you need to take your scientific illustration to the next level!
You know the drill. To prove your theory, you must show the colocalization of X and Y in a cell. Here are 2 ways to reveal protein colocalization.
Whether you want to get started with fluorescence microscopy or already use it, this guide will ensure you know the basics and get the best out of your fluorescence microscopy.
Not sure what FRET is, or just need a refresher on how FRET works? Read our short guide to understand the usefulness of FRET for studying protein-protein interactions.
Oil immersion microscopy can improve your resolution in microscopy. This article will explain why this is the case and how you can use oil immersion microscopy in the lab!
You don’t have to be a genius to understand Cryo-EM. Discover the fundamentals of this powerful microscopy tool and what propelled it into the scientific mainstream.
The slow, inching progress of cryo-EM towards the scientific mainstream can be told as a story with three parts. So take a step back and enjoy a short history of cryo-electron microscopy.
You don’t have to be a brainbox to get your samples ready for cryo-EM, but a little wisdom goes a long way. Learn how to tend to your tissues, organize your organelles, and prepare your proteins to get the micrographs you’ve always dreamed of.
Microscopy is a huge and active field. Sometimes, it’s easy to forget the basics. Read our biologists’ guide to electron microscopy techniques.
Microscopy is a huge and active field. Sometimes, it’s easy to forget the basics. Read our biologists’ intro to applications of electron microscopy.
Discover 6 critical scanning electron microscopy sample preparation points you need to know to get the best out of your SEM.
Discover how you can visualize that notoriously difficult molecule, RNA using light-up RNA aptamers (LURAs).
Discover the critical considerations when choosing a fluorescent protein, the key features of those most commonly used, and why newer might be better.
How you fix your tissue or cells can affect your results, for better or for worse. Discover the key points to think about before undertaking your histology fixation.
Discover the history of histology, from the first mention of a cell in 1665 to the identification and development of various stains.
Discover seven common histology mistakes and how you can avoid making them when performing your experiments.
Do you know what that NA number is on your objective? We walk you through what the numerical aperture is and why it’s important.
There are a large number of microscope objective abbreviations relating to optical aberrations; here we’ll shed some light on some of the most common ones to get you up to speed in no time!
Live imaging of phagocytosis helps capture the details of this dynamic process. Discover tips and tricks to visualizing this important cellular process.
Learn how the Point Spread Function affects what you see through your microscope and discover what you can do to improve your images.
Live-cell imaging can bring a lot of clarity to cellular processes, but keeping your cells happy can be tricky. Read on to learn about 4 key parameters for achieving optimal conditions for live-cell imaging.
Read on to learn more about live cell imaging, including how high rate microscopy can help you capture rapid cellular processes.
Discover how chromatic and geometric imaging aberrations have been corrected over the last few centuries with the development of corrected lenses and objectives.
Discover the history of simple and compound microscopes in this first of our two-part series on the history of microscopes.
Are you having problems with tissue sectioning? Follow these 10 tissue sectioning tips to create the perfect tissue section every time without stressing out.
Want to know about stereo microscopes? This article answers what a stereo microscope is, how it works and why it’s a great tool for biologists!
Getting publication perfect confocal images can be tricky. If you are struggling or just want to ensure you’re capturing the best images possible, check out our top 7 tips for confocal imaging.
Get the best out of your time on the microscope by understanding the refractive index of your experiment to optimize and increase your resolution.
If you’re thinking FRAP is short for frappuccino then you need to read this article. Discover the history, how it works, and why you’d want it in your confocal toolbox
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