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Microscopy and Imaging

Intravital Microscopy of Cancer

LIVE WebinarIntravital Microscopy of Cancer Tuesday 29th June 2021 LONDON 16:00 BST | BERLIN 17:00 CET | DUBAI 19:00 GST In this webinar, you will learn: about intravital microscopy techniques that allow you to monitor stem cells and cancer cells in real-time in vivo; how these techniques can help you study the identity and migratory…

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Optimal Conditions for Live-Cell Imaging

Live-cell imaging can bring a lot of clarity to cellular processes, but keeping your cells happy can be tricky. Read on to learn about 4 key parameters for achieving optimal conditions for live-cell imaging.

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Visualising protein degradation and aggregation in the living cell

Visualising protein degradation and aggregation in the living cell Available On Demandat MicroscopyFocus.com Watch Now In this webinar, Prof. Eric Reits will discuss how several neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Huntington’s disease, are characterized by the formation of protein aggregates, and that components of the ubiquitin-proteasome system (UPS) co-localize in these aggregates. This has…

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Life beyond the pixels: deep learning methods for single cell analysis

Life beyond the pixels:Deep learning methods for single cell analysis Available On Demand In this webinar, you will discover: the computational steps in the analysis of single cell-based large-scale microscopy experiments; a novel microscopic image correction method designed to eliminate illumination and uneven background effects; new single-cell image segmentation methods; the Advanced Cell Classifier, a…

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See The Hidden: Virtual Neurosciences Workshop

See The Hidden: Virtual Neurosciences Workshop This live online event brings together a series of scientific talks and microscopy showcases, centering around four specific topics in microscopy – 3D real time imaging*, laser microdissection, confocal nanoscopy and high pressure freezing techniques in electron microscopy. Each section will kick off with a scientific talk from one…

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UltraMicroscope Blaze™ live instrument demonstration

UltraMicroscope Blaze™ live instrument demonstration Available On-Demand Register & Watch Now This live demonstration introduces you directly to the Ultramicroscope Blaze, a fully-automated, multi-scale, high-resolution, light sheet imaging system for high throughput volumetric imaging of large biological samples. Our imaging team will demonstrate the ease-of-use and performance of the instrument and take you through the…

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The UltraMicroscope Blaze™: Automated 3D imaging on an unprecedented scale

The UltraMicroscope Blaze™: Automated 3D imaging on an unprecedented scale Available On-Demand Register & Watch Now This webinar introduces the brand new Ultramicroscope Blaze. This next-generation light sheet imaging system brings together more than a decade of light sheet fluorescence microscopy (LSFM) development and collaboration. The Blaze is a fully-automated light sheet imaging system with,…

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Mesoscopic Whole-Organ Imaging: Experimental Models and Diagnostic Potential

Mesoscopic Whole-Organ Imaging: Experimental Models and Diagnostic Potential Available On-Demand Register & Watch Now Cellular interactions and thus organ function and anatomy are inherently of a three-dimensional (3D) nature. Knowledge of the cellular distribution patterns within organs, in both health and disease states, is critical to our understanding of ongoing microscopic processes on a mesoscopic…

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Exploring The Structure and Life Cycle of Viruses

Exploring The Structure and Life Cycle of Viruses The Virologist’s Toolbox for Electron Microscopy Specimen Preparation Available On Demand Speakers Frédéric Leroux Advanced Workflow SpecialistLeica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to…

Electron microscopy image of virus particles demonstrating the usefulness of electron microscopy of viruses and virologyRead More

Ask Eric Anything
A live episode of The Microscopists featuring Eric Betzig

Ask Eric Anything A live episode of The Microscopists featuring Eric Betzig On-Demand Ask Eric Anything: A live episode of The Microscopists featuring Eric Betzig On-Demand The Microscopists is going LIVE! For a one-off and very special guest – Eric Betzig! We already know so much about Eric, but I hope that our chat will…

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Tissue Processing For Histology: What Exactly Happens?

When preparing a sample (or multiple samples) for histology microscopy, there are multiple steps required. We’ve covered these steps in brief in a previous article on How Histology Slides are Prepared, but this article will focus on one particular procedure that needs to take place between tissue fixation and the embedding/sectioning of paraffin blocks: tissue…

histology image of large intestine to depict tissue processing for histologyRead More

From Organs to Tissues to Cells: Analyzing 3D Specimens with Widefield Microscopy

From Organs to Tissues to Cells: Analyzing 3D Specimens with Widefield Microscopy On Demand Speakers Dr. Falco Krüger Advanced Workflow Specialist Widefield Life Science Research DivisionLeica Microsystems Falco did his PhD in Biology at the Plant Cell Biology chair of Prof. Karin Schumacher at the Centre for Organismal Studies (COS) in Heidelberg, Germany. For his…

HeLa cell spheroid - THUNDER Imager 3D Live Cell & 3D Cell CultureRead More

Revealing functional mechanisms of synaptic transmission by high-pressure freezing

Revealing functional mechanisms of synaptic transmission by high-pressure freezing On Demand Speakers Frédéric Leroux Advanced workflow specialist, Leica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to the physics department at the University of…

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Making the Perfect Blood Smear

Stop wasting time throwing out slide after slide trying to create a readable blood smear. Read our how-to guide for creating the perfect blood smear slide.

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What Can Electron Microscopy Do for You?

The electron microscope (EM) – where electrons, rather than photons, make the image – fell out of fashion for a while, but it has come back refreshed. Modern electron microscopes cost less, use less electricity, and are generally easier to maintain than the older models, so it is likely that you can get your hands on one. Read on to learn more about this technique, and how to implement it into your research.

Transmission electron microscopy of the nuclear envelopeRead More

Workflows and instrumentation for cryo-electron microscopy: an overview

Workflows and instrumentation for cryo-electron microscopy: an overview Now On Demand Speaker Frédéric Leroux Advanced workflow specialist, Leica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to the physics department at the University of…

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Microscope Disinfection: A Quick Guide

Shared microscopes have the potential to get dirty and spread nasties between samples and users. Check out our quick guide on how to clean and disinfect your microscope.

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Making a Mark: How to Set up Your Wound Healing Assay 

Are you wanting to study cell migration and need a way to quantify it? A wound healing assay is one of the earliest and simplest in-vitro assays developed to study cell migration. Collective cell migration is a characteristic behaviour seen in wound repair, cancer invasion, cancer metastasis, immune response, angiogenesis and embryonic morphogenesis. Depending on…

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How to Totally Nail Your First in situ Hybridization

It’s Monday morning and you’re about to start your first in situ hybridization (ISH). You glanced at the protocol on Friday and it seemed pretty easy. You just do a lot of washes and incubations, right? WRONG. ISH can be a nightmare. If you’re not well prepared, you’ll most likely be tearing your hair out…

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Controls for Immunofluorescence: A Beginner’s Guide 

Immunofluorescence staining is a popular and extremely powerful detection method. However, achieving publication quality immunofluorescence or fluorescent antibody staining can get tricky. It’s therefore important to ensure you have the right controls for immunofluorescence.   Since immunofluorescence staining is a long process with many steps, it is always advisable to spend some time optimizing each…

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Optimized cryo workflows using the vacuum cryo transfer system VCT500

Optimized cryo workflows using the vacuum cryo transfer system VCT500 In this tutorial, you will find: How to use the vacuum cryo transfer system The advantages of the EM VCT500 and EM VCM for different cryo workflows About their flexible integration with different analysis systems Speakers Dr. Julia KönigProduct Manager EM sample preparation for cryo-workflows…

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THUNDER Imagers: High performance, versatility and ease-of-use for your everyday imaging workflows.

THUNDER Imagers: High performance, versatility and ease-of-use for your everyday imaging workflows. In this webinar, you will learn: How to get sharp, high quality images from thick 3-dimensional microscope samples How to shorten your imaging workflow from image acquisition to data analysis A broad spectrum of imaging workflows for a range of life science applications…

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