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Microscopy and Imaging

Visualising protein degradation and aggregation in the living cell

Visualising protein degradation and aggregation in the living cell Available On Demandat MicroscopyFocus.com Watch Now In this webinar, Prof. Eric Reits will discuss how several neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Huntington’s disease, are characterized by the formation of protein aggregates, and that components of the ubiquitin-proteasome system (UPS) co-localize in these aggregates. This has…

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Life beyond the pixels: deep learning methods for single cell analysis

Life beyond the pixels:Deep learning methods for single cell analysis Available On Demand In this webinar, you will discover: the computational steps in the analysis of single cell-based large-scale microscopy experiments; a novel microscopic image correction method designed to eliminate illumination and uneven background effects; new single-cell image segmentation methods; the Advanced Cell Classifier, a…

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See The Hidden: Virtual Neurosciences Workshop

See The Hidden: Virtual Neurosciences Workshop This live online event brings together a series of scientific talks and microscopy showcases, centering around four specific topics in microscopy – 3D real time imaging*, laser microdissection, confocal nanoscopy and high pressure freezing techniques in electron microscopy. Each section will kick off with a scientific talk from one…

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UltraMicroscope Blaze™ live instrument demonstration

UltraMicroscope Blaze™ live instrument demonstration Available On-Demand Register & Watch Now This live demonstration introduces you directly to the Ultramicroscope Blaze, a fully-automated, multi-scale, high-resolution, light sheet imaging system for high throughput volumetric imaging of large biological samples. Our imaging team will demonstrate the ease-of-use and performance of the instrument and take you through the…

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The UltraMicroscope Blaze™: Automated 3D imaging on an unprecedented scale

The UltraMicroscope Blaze™: Automated 3D imaging on an unprecedented scale Available On-Demand Register & Watch Now This webinar introduces the brand new Ultramicroscope Blaze. This next-generation light sheet imaging system brings together more than a decade of light sheet fluorescence microscopy (LSFM) development and collaboration. The Blaze is a fully-automated light sheet imaging system with,…

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Mesoscopic Whole-Organ Imaging: Experimental Models and Diagnostic Potential

Mesoscopic Whole-Organ Imaging: Experimental Models and Diagnostic Potential Available On-Demand Register & Watch Now Cellular interactions and thus organ function and anatomy are inherently of a three-dimensional (3D) nature. Knowledge of the cellular distribution patterns within organs, in both health and disease states, is critical to our understanding of ongoing microscopic processes on a mesoscopic…

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Exploring The Structure and Life Cycle of Viruses

Exploring The Structure and Life Cycle of Viruses The Virologist’s Toolbox for Electron Microscopy Specimen Preparation Available On Demand Speakers Frédéric Leroux Advanced Workflow SpecialistLeica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to…

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Ask Eric Anything
A live episode of The Microscopists featuring Eric Betzig

Ask Eric Anything A live episode of The Microscopists featuring Eric Betzig On-Demand Ask Eric Anything: A live episode of The Microscopists featuring Eric Betzig On-Demand The Microscopists is going LIVE! For a one-off and very special guest – Eric Betzig! We already know so much about Eric, but I hope that our chat will…

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From Organs to Tissues to Cells: Analyzing 3D Specimens with Widefield Microscopy

From Organs to Tissues to Cells: Analyzing 3D Specimens with Widefield Microscopy On Demand Speakers Dr. Falco Krüger Advanced Workflow Specialist Widefield Life Science Research DivisionLeica Microsystems Falco did his PhD in Biology at the Plant Cell Biology chair of Prof. Karin Schumacher at the Centre for Organismal Studies (COS) in Heidelberg, Germany. For his…

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Revealing functional mechanisms of synaptic transmission by high-pressure freezing

Revealing functional mechanisms of synaptic transmission by high-pressure freezing On Demand Speakers Frédéric Leroux Advanced workflow specialist, Leica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to the physics department at the University of…

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Making the Perfect Blood Smear

Stop wasting time throwing out slide after slide trying to create a readable blood smear. Read our how-to guide for creating the perfect blood smear slide.

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What Can Electron Microscopy Do for You?

The electron microscope (EM) – where electrons, rather than photons, make the image – fell out of fashion for a while, but it has come back refreshed. Modern electron microscopes cost less, use less electricity, and are generally easier to maintain than the older models, so it is likely that you can get your hands on one. Read on to learn more about this technique, and how to implement it into your research.

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Workflows and instrumentation for cryo-electron microscopy: an overview

Workflows and instrumentation for cryo-electron microscopy: an overview Now On Demand Speaker Frédéric Leroux Advanced workflow specialist, Leica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to the physics department at the University of…

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Microscope Disinfection: A Quick Guide

Shared microscopes have the potential to get dirty and spread nasties between samples and users. Check out our quick guide on how to clean and disinfect your microscope.

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Making a Mark: How to Set up Your Wound Healing Assay 

Are you wanting to study cell migration and need a way to quantify it? A wound healing assay is one of the earliest and simplest in-vitro assays developed to study cell migration. Collective cell migration is a characteristic behaviour seen in wound repair, cancer invasion, cancer metastasis, immune response, angiogenesis and embryonic morphogenesis. Depending on…

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How to Totally Nail Your First in situ Hybridization

It’s Monday morning and you’re about to start your first in situ hybridization (ISH). You glanced at the protocol on Friday and it seemed pretty easy. You just do a lot of washes and incubations, right? WRONG. ISH can be a nightmare. If you’re not well prepared, you’ll most likely be tearing your hair out…

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Optimized cryo workflows using the vacuum cryo transfer system VCT500

Optimized cryo workflows using the vacuum cryo transfer system VCT500 In this tutorial, you will find: How to use the vacuum cryo transfer system The advantages of the EM VCT500 and EM VCM for different cryo workflows About their flexible integration with different analysis systems Speakers Dr. Julia KönigProduct Manager EM sample preparation for cryo-workflows…

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THUNDER Imagers: High performance, versatility and ease-of-use for your everyday imaging workflows.

THUNDER Imagers: High performance, versatility and ease-of-use for your everyday imaging workflows. In this webinar, you will learn: How to get sharp, high quality images from thick 3-dimensional microscope samples How to shorten your imaging workflow from image acquisition to data analysis A broad spectrum of imaging workflows for a range of life science applications…

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Understanding Malaria Parasite Pathogenesis by Cryo-Electron Microscopy

Understanding Malaria Parasite Pathogenesis by Cryo-Electron Microscopy In this tutorial, you will learn: The mechanisms by which the plasmodium translocon of exported proteins (PTEX)  enables the  Plasmodium parasite to take over red blood cells How single-particle cryo-electron microscopy enables us to gain insight into the PTEX molecular structure The opportunity this presents for structure-based design…

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An Introduction to Digital Images in Publications

Previously, I wrote about the different ways to use scientific illustration to communicate research. In this article, I will introduce the technical aspects of digital images and the most common image file types that scientists will encounter when preparing images for publication. Raster Versus Vector Digital images are classified based on how information is stored.…

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Basics of Fluorescence Lifetime Imaging and FLIM Applications to FRET Biosensors

Basics of Fluorescence Lifetime Imaging and FLIM Applications to FRET Biosensors In this tutorial you will learn: How researchers (Anzilotti 2019) used FLIM to elucidate the mechanisms responsible for a B cell deficiency A new approach to measure the cellular function of the Zn2+ transporter ZIP7 in primary mouse cells, comparing wild-type and CRISPR-Cas9 derived mutant cells…

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How to Weigh Molecules with Light Using Mass Photometry

How to Weigh Molecules with Light Using Mass Photometry In this tutorial, you will learn:    How mass photometry offers a universal way to study biomolecules    The strengths and limitations of mass photometry    How to use mass photometry to: accurately determine the degree of heterogeneity of a sample quantify the strength and kinetics of molecular interactions…

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The New ZEISS LSM 9 Family: Adding the Multiplex Factor to Your Confocal Imaging

The New ZEISS LSM 9 Family: Adding the Multiplex Factor to Your Confocal Imaging In this tutorial on confocal imaging, you will learn how you can: Capture weaker signals—and still get sound, reproducible data. Reach faster volumetric imaging without sacrificing resolution Increase data throughput for your imaging needs Speaker Joseph HuffSolution Manager/Application Development Engineer at…

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