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Genomics and Epigenetics

CRISPR Screening: from design and discovery to validation

CRISPR Screening: from design and discovery to validation Date: Wednesday 9th December 2020Broadcast 1: 9 am Moscow, 11.30 am Delhi, 2 pm Beijing, 3 pm TokyoBroadcast 2: 4 pm London, 5 pm Berlin, 8 am Los Angeles, 11 am New York Speaker Gillian Browne, PhD Global Head of Commercial Enablement, Genome Engineering & ModulationMilliporeSigma Gillian received…

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Optimizing CRISPR mouse model pipelines – modified synthetic sgRNAs

Optimizing CRISPR mouse model pipelines – modified synthetic sgRNAs On Demand Speaker Matthew Mackenzie Resource Support ManagerMRC Harwell Matthew Mackenzie earned a BSc in Genetics at the University of Liverpool, where he spent a year in industry with LGC Forensics (now Eurofins) gaining insights into high-throughput sample analysis and automation. After graduating in 2015 he…

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A guide to leveraging single cell CRISPR screens for deeper biological insights

A guide to leveraging single cell CRISPR screens for deeper biological insights On Demand Speakers Andrew Ravanelli, Ph.D. Senior R&D Scientist, Genome and Epigenome Editing, Merck KGaA, Darmstadt, Germany Andrew obtained his Ph.D. in Cell Biology from Duke University, where he used mouse and zebrafish models to dissect cellular mechanisms of early tissue formation. He…

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Markerless and Scarless Microbial Genome Engineering

Markerless and Scarless Microbial Genome Engineering On Demand Webinar Speaker Erik Eastlund Principal Scientist, Gene Editing and Novel Modalities, Merck KGaA, Darmstadt, Germany Erik is a principal scientist for Gene Editing and Novel Modalities at Merck KGaA, Darmstadt, Germany. His group is focused on developing microbial genome engineering tools while also engaging in a microbiome…

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Efficient Generation of Gene-edited Mouse Models and Cell Lines Using Synthetic sgRNA

Efficient Generation of Gene-edited Mouse Models and Cell Lines Using Synthetic sgRNA On Demand Webinar Dr. Peter Romanienko Managing Director, Genome Editing Shared Resource, Rutgers-Cancer Institute of New Jersey Dr. Peter Romanienko obtained his PhD training from Cornell Graduate School of Medical Sciences/Sloan Kettering Institute working on DNA repair in Dr. Maria Jasin’s laboratory and…

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How CRISPR Can Be Used to Detect Emerging Viral Pathogens

The threat of pandemic viruses can be mitigated by developing diagnostic tests that are rapidly implementable and field deployable. Two CRISPR-based strategies, DETECTR and SHERLOCK, have been developed recently that not only meet these criteria but offer unprecedented multiplexing capabilities. This article discusses the theoretical basis of proposed and currently available viral diagnostics for educational…

A detective dressed like a detective to symbolize the DETECTR and SHERLOCK CRISPR methods for Viral diagnosis.Read More

Plant vs. Virus: Comparative transcriptomic analysis of single TuMV-infected micro-dissected plant cells

Plant vs. Virus: Comparative transcriptomic analysis of single TuMV-infected micro-dissected plant cells In this tutorial, you will find: How studying the early events of virus infection in plants avoids the dilution effect and allows identification of the key molecular players involved in initial plant-virus interactions.  How the MMI CellCut microdissection system allows dissection of the…

Arabidopsis thaliana in test tubes to depict study of viral infection of plants.Read More

Engineering Vero Cell Lines Using CRISPR to Increase Production of Viral Vaccines

Engineering Vero Cell Lines Using CRISPR to Increase Production of Viral Vaccines On Demand Webinar Dr. Benjamin Borgo Dr. Benjamin Borgo currently leads a team of forward-thinking product and service managers within Merck KGaA’s Genome Engineering and Modulation franchise. His first exposure to CRISPR-based genome editing was as a graduate student where he attempted to…

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WGS Workflow: From Sample Collection to Data Interpretation

The efficiency of whole genome sequencing (WGS) workflows has skyrocketed since its inception. Major leaps and minor tweaks in the WGS workflow have compounded over time resulting in radical reductions in processing time and the cost of sequencing whole genomes over the past decades. The complete sequencing of the first human genome, named the Human…

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