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Genomics and Epigenetics

Detecting Low-Abundant Neurofilament Light Chain

Detecting Low-Abundant Neurofilament Light Chain Available On-Demand Speaker Rick Wiese, Ph.D. Head of Singleplex & Special Protein Platforms R&DMerck KGaA, Darmstadt, Germany Rick Wiese holds a PhD from FDA NCTR and has over 22 years of experience in immunoassay development and production. In 2007, he became R&D Manager for the MILLIPLEX® assay group and then…

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Introduction to Liquid Handling for NGS Workflows

Introduction to Liquid Handling for NGS Workflows Date: Thursday May 19th 2022Available On Demand Speakers Elisa Viering Product Marketing Manager Elisa joined Eppendorf in 2021 as a Product Marketing Manager for automated Liquid Handling and PCR devices. She has previous experience as a Global Product Manager for automated electrophoresis solutions and as a Laboratory Engineer…

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Monitoring adoptive cell therapy using immunosequencing

Monitoring adoptive cell therapy using immunosequencing Date: Thursday, April 28th 2022Time: 8am Los Angeles, 10am Chicago, 11am New York, 4pm London, 5pm Berlin Adoptive cellular and CAR-T immunotherapies have the potential to revolutionize the treatment of patients with various solid tumors and blood cancers, where patients’ T cells are extracted, modified and reinfused. As this…

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Accelerating discovery with the immunoSEQ® HLA Classifier

Accelerating discovery with the immunoSEQ® HLA Classifier Thursday, March 17th 2022 8am Los Angeles, 10am Chicago, 11am New York, 3pm London, 4pm Berlin Classic major histocompatibility complex (MHC) proteins, also known as human leukocyte antigen proteins (HLA) in humans, play an essential role in immune function and regulation, including influencing the composition of the T-cell…

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Boosting signal-to-noise in single cell RNA-seq through molecular depletion

Boosting signal-to-noise in single cell RNA-seq through molecular depletion Available On Demand Speaker Jon Bezney Research Associate III,Research & Development,Jumpcode Genomics  Jon Bezney is a Research Associate III at Jumpcode Genomics. Jon received his Bachelor of Science from Yale University in molecular biology. He then spent three years at the Broad Institute of MIT and…

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Functional Genomics Screening: From Knockout and Modulation to Single Cell Analysis

Functional Genomics Screening: From Knockout and Modulation to Single Cell Analysis Available On Demand Speaker Gurpreet Balrey, PhD Head of Global Commercial Enablement and EMEA Business HeadMerck KGaA, Darmstadt, Germany Gurpreet attended the University of Nottingham for a Biotechnology degree followed by a PhD in Molecular Biology and Plant Genetic Engineering at the same University.…

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Understanding gum diseases by integrating multiplexed-technologies in the microbiome and immunological analysis

Understanding gum diseases by integrating multiplexed-technologies in the microbiome and immunological analysis Available On Demand Speakers Dr. Renato Corrêa Viana Casarin Unicamp Dr. Casarin has a MSc and Ph.D. in Periodontics from the Piracicaba Dental School, State University of Campinas – UNICAMP. He is currently an associate professor in Periodontics at the Piracicaba Dental School.…

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Quick and Easy Sequencing of SARS-CoV-2 to Identify Variants of Concern

Quick and Easy Sequencing of SARS-CoV-2 to Identify Variants of Concern Available On Demand Speaker Jordan RoseFigura, PhD Director of Material SciencesSwift Biosciences Dr. Jordan RoseFigura completed her Ph.D. in Chemistry at UC Berkeley where she studied the mechanism of PQQ formation. She then took up an NIH Postdoctoral Fellowship at The Rockefeller University where…

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Screening in the Modern CRISPR Era

Screening in the Modern CRISPR Era Available On Demand Speaker Andrew Ravanelli Principal Scientist, Genome and Epigenome EditingMerck KGaA, Darmstadt, Germany Andrew obtained his Ph.D. in Cell Biology from Duke University, where he used mouse and zebrafish models to dissect cellular mechanisms of early tissue formation. He completed a postdoctoral fellowship in Pediatrics at the…

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CRISPR Screening: from design and discovery to validation

CRISPR Screening: from design and discovery to validation On Demand Speaker Gillian Browne, PhD Global Head of Commercial Enablement, Genome Engineering & ModulationMilliporeSigma Gillian received a BSc in Biomedical Sciences, followed by a PhD in Cellular and Molecular Cancer Biology in the UK. She pursued five years of postdoctoral research in the USA and during…

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Optimizing CRISPR mouse model pipelines – modified synthetic sgRNAs

Optimizing CRISPR mouse model pipelines – modified synthetic sgRNAs On Demand Speaker Matthew Mackenzie Resource Support ManagerMRC Harwell Matthew Mackenzie earned a BSc in Genetics at the University of Liverpool, where he spent a year in industry with LGC Forensics (now Eurofins) gaining insights into high-throughput sample analysis and automation. After graduating in 2015 he…

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A guide to leveraging single cell CRISPR screens for deeper biological insights

A guide to leveraging single cell CRISPR screens for deeper biological insights On Demand Speakers Andrew Ravanelli, Ph.D. Senior R&D Scientist, Genome and Epigenome Editing, Merck KGaA, Darmstadt, Germany Andrew obtained his Ph.D. in Cell Biology from Duke University, where he used mouse and zebrafish models to dissect cellular mechanisms of early tissue formation. He…

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Markerless and Scarless Microbial Genome Engineering

Markerless and Scarless Microbial Genome Engineering On Demand Webinar Speaker Erik Eastlund Principal Scientist, Gene Editing and Novel Modalities, Merck KGaA, Darmstadt, Germany Erik is a principal scientist for Gene Editing and Novel Modalities at Merck KGaA, Darmstadt, Germany. His group is focused on developing microbial genome engineering tools while also engaging in a microbiome…

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Efficient Generation of Gene-edited Mouse Models and Cell Lines Using Synthetic sgRNA

Efficient Generation of Gene-edited Mouse Models and Cell Lines Using Synthetic sgRNA On Demand Webinar Dr. Peter Romanienko Managing Director, Genome Editing Shared Resource, Rutgers-Cancer Institute of New Jersey Dr. Peter Romanienko obtained his PhD training from Cornell Graduate School of Medical Sciences/Sloan Kettering Institute working on DNA repair in Dr. Maria Jasin’s laboratory and…

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Plant vs. Virus: Comparative transcriptomic analysis of single TuMV-infected micro-dissected plant cells

Plant vs. Virus: Comparative transcriptomic analysis of single TuMV-infected micro-dissected plant cells In this tutorial, you will find: How studying the early events of virus infection in plants avoids the dilution effect and allows identification of the key molecular players involved in initial plant-virus interactions.  How the MMI CellCut microdissection system allows dissection of the…

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Engineering Vero Cell Lines Using CRISPR to Increase Production of Viral Vaccines

Engineering Vero Cell Lines Using CRISPR to Increase Production of Viral Vaccines On Demand Webinar Dr. Benjamin Borgo Dr. Benjamin Borgo currently leads a team of forward-thinking product and service managers within Merck KGaA’s Genome Engineering and Modulation franchise. His first exposure to CRISPR-based genome editing was as a graduate student where he attempted to…

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WGS Workflow: From Sample Collection to Data Interpretation

The efficiency of whole genome sequencing (WGS) workflows has skyrocketed since its inception. Major leaps and minor tweaks in the WGS workflow have compounded over time resulting in radical reductions in processing time and the cost of sequencing whole genomes over the past decades. The complete sequencing of the first human genome, named the Human…

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The Recipe for Successful Whole Genome Sequencing

The success of whole genome sequencing (WGS) is shown in the quick and efficient scientific response to the 2011 outbreak of E. coli in Germany and France.1 German and French strains of E. coli were indistinguishable using standard tests.  However, WGS analysis showed 2 single nucleotide polymorphisms (SNPs) in the German strains and 9 SNPs…

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A Colorful Route to Sequencing Success

An oft-repeated maxim in biological bench science is that any experiment is only as good as its control. A control is an unchanging standard of comparison in an experiment, and an internal control is typically a standard reaction run together with the test reaction in the same reaction mixture. The purpose of an internal control…

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CRISPR Multiplexing Strategies: What’s The Choice?

Although multiplex CRISPR gene editing can be accomplished by simply introducing more than one gRNA to your target cells, there are many alternative — and more efficient — ways of achieving this goal. This article discusses these alternative CRISPR multiplexing strategies and highlights their potential caveats. Not sure whether multiplex CRISPR gene editing is right…

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