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Applying Cell Sorting in Clinical Immunology Research
Using Integrative Spatial Biology to Study the Mouse Brain
Illuminating Nanomaterial–Cell Interactions by Confocal Microscopy
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Democratizing Nanoscale Imaging at Molecular Resolution
Human Dendritic Spine Analysis and Neurological Disorders
Decoding Early Disease Risk Using Region-specific Genomics
Advancing GxP-ready Microscopy: From Qualification to Data Integrity
Faster Single Cell Isolation for High-quality Cell Line Development
Latest Articles
Writing, Publishing and Presenting
Using Scientific Animation to Present Complex Biological Mechanisms
Biological mechanisms are, by their nature, dynamic. They involve interaction, causality, and specific sequences that unfold over time. Standard scientific communication, however, tends to use static media that cannot represent time. This means that when you show a complex signalling pathway on a slide, your audience must first decode the spatial relationships, then infer the…
Latest Podcasts
Gel and blot imaging has come a long way. Film gave you sensitivity but slowed you down with darkrooms and inconsistent results. Camera systems sped things up but still left you fighting noise and limited dynamic range. Laser imaging now gives you cleaner signals, sharper focus, and far more flexibility across sample types.
When interpreting cellular metabolism assays, focusing on single pathways can be misleading, as metabolism operates as a connected network. Metabolites such as pyruvate, malate, glycogen, branched-chain amino acids, and β-hydroxybutyrate sit at key metabolic crossroads, where changes reflect shifts in energy routing, redox balance, and stress adaptation. Understanding these junctions helps you evaluate metabolic data more accurately and design experiments that capture the true cellular state.
The traditional career pathway for most scientists is to get a degree, a postdoc, and then a permanent position. But in the 21st century, a PhD no longer ensures security or a smooth career path. Your career plan is in your hands, and this means you must proactively control your professional identity. Two forces are challenging…
IC₅₀ and Kd are widely used in drug discovery, but they answer different questions. This article explains how to interpret IC₅₀ and Kd correctly, why they’re not directly comparable, and how combining both metrics leads to better compound prioritization and decision-making.
Microscopy & Imaging
Optical microscopy has always been restricted by the diffraction of light. Because conventional widefield and confocal microscopes cannot resolve structures substantially smaller than about 200nm laterally, they miss critical signaling compartments and nanoscopic organization. Newer super-resolution technologies, such as stimulated emission depletion (STED), structured illumination microscopy (SIM), and photoactivated localization microscopy (PALM), solve this problem…
DNA / RNA Manipulation & Analysis
Unsure which next-generation sequencing (NGS) method to choose for your cancer and precision medicine research? Learn about the latest tools and tailored next-generation sequencing solutions for cancer research in this short guide.
How-To Guides
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