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Thomas Warwick

I’m a Chemistry graduate who defected to the world of biosciences to complete a Ph.D. in Structural Biology. My expertise lies in the structural analysis of chemicals, membrane proteins, and protein/DNA complexes via X-ray crystallography. I currently work as a Technical Specialist in Biophysics at Nottingham Trent University. My antidote to practical science is to be outside as much as possible, usually cycling, camping, and drinking tea.

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Articles by Thomas Warwick

child stacking books on his head to represent a transfer stack and how to optimize your Western blot transfer

3 Hot Tips to Optimize Your Western Blot Transfers

By Thomas Warwick | November 4, 2022

Are you struggling with ugly and unreadable western blots? Here are 3 ways to optimize your western blot transfer and get blots to be proud of.

CCoffee being filtered in a funnel filter to representing purification of molecules in size-exclusion chromatography

How to Measure Molecular Weight Using Size-Exclusion Chromatography (SEC)

By Thomas Warwick | October 28, 2022

We often use size-exclusion chromatography to purify samples. Read this article to learn how to use it to measure sample molecular weight as well!

A man covered in notes and paper indicating under preparedness for journal club

Journal Club: How to Prepare Effectively and Smash Your Presentation

By Thomas Warwick | September 14, 2022

Journal Club. So much more than reading a paper aloud. So many ways to mess it up. Got to present one? Then read our journal club toolkit.

Somebody holding a flask of blue solution to symbolize buffers in how do buffers work

How Do Buffers Work?

By Thomas Warwick | September 12, 2022

Buffers provide a stable chemical environment for all our experiments. But how do buffers work? And how do you pick one? Read on to find out.

A researcher surrounded by numerous dangerous chemicals considering the 10 golden rules for working safely in the lab.

10 Golden Rules to Working Safely in the Lab: What Chemists Wish Biologists Knew

By Thomas Warwick | August 30, 2022

Working with chemicals is dangerous and can lead to injury, or worse. Follow these ten broadly applicable golden rules to help keep you and your colleagues working safely in the lab.

A skeleton wearing goggles being attacked by acid and piranhas thinking about how to handle strong acids.

How to Handle Strong Acids in the Lab

By Thomas Warwick | July 5, 2022

Acids are common and essential chemicals in any research laboratory. In this article, you’ll get advice on how to handle strong acids safely to give you the confidence to routinely prepare, handle, and dispose of them in the lab.

Daughter mimics dad as a superhero to highlight how researchers can mimic phosphorylation

3 Easy Ways to Mimic Phosphorylation 

By Thomas Warwick | May 10, 2022

Discover what phosphorylation is, understand why you might want to mimic it, and learn 3 ways to mimic phosphorylation for both in vitro and in vivo applications

A graphic of a fist punching the air to describe the concept of what is Cryo-Electron microscopy

What Is Cryo-Electron Microscopy? A Brief Introduction

By Thomas Warwick | April 26, 2022

You don’t have to be a genius to understand Cryo-EM. Discover the fundamentals of this powerful microscopy tool and what propelled it into the scientific mainstream.

An image of parchment and quill pen to depict the history of Cryo-Electron Microscopy

A Short History of Cryo-Electron Microscopy

By Thomas Warwick | April 19, 2022

The slow, inching progress of cryo-EM towards the scientific mainstream can be told as a story with three parts. So take a step back and enjoy a short history of cryo-electron microscopy.

Explorer in a cave of ice to represent the extreme temperatures required during cryo-EM sample prep

Cryo-EM Sample Prep: 5 Crucial Considerations 

By Thomas Warwick | April 12, 2022

You don’t have to be a brainbox to get your samples ready for cryo-EM, but a little wisdom goes a long way. Learn how to tend to your tissues, organize your organelles, and prepare your proteins to get the micrographs you’ve always dreamed of.

A bowl of peas as a visual metaphor for the letter P in the question: What is pH?

The Definitive Guide to pH, pKa, and pI

By Thomas Warwick | March 4, 2022

We all rely on pH, pKa, and pI for a vast amount of our research. But what is pH? How does it relate to pKa and pI? Read the definitive guide.

An image of items related to construction to convey structural information contained in a protein data bank file

Protein Structure Analysis: Extra Information in a Protein Data Bank File

By Thomas Warwick | March 3, 2022

Getting to know your protein’s structure can help uncover deeper insights and inspire new hypotheses. Discover how protein data bank files can help.

An image of a spiral staircase to depict circular dichroism sample preparation.

An Introduction to Circular Dichroism Part 2: Circular Dichroism Practice

By Thomas Warwick | February 8, 2022

Circular dichroism is a type of spectroscopy that can tell you the type and percentage of secondary structure units in a protein sample. Here are 5 handy pointers on best circular dichroism practice to set up your experiment properly.

An image of a spiral color spectrum to depict the principle of circular dichroism.

An Introduction to Circular Dichroism Part 1: Circular Dichroism Theory

By Thomas Warwick | February 1, 2022

Circular dichroism is a type of spectroscopy that can tell you the type and percentage of secondary structure units in a protein sample. This article will take you through circular dichroism theory and some of its applications.

Layered cocktails representing SDS-PAGE Gel Recipe

A Simple SDS-PAGE Gel Recipe and 10-Step Casting Protocol for Perfect Gels

By Thomas Warwick | January 25, 2022

SDS-PAGE is the technique that unites life scientists. We all perform it during our research to separate protein analytes and, therefore, we all need a good SDS-PAGE gel recipe.

An image of snow crystals to depict protein crystallization seeding

5 Protein Crystallization Seeding Techniques for Bigger and Better Crystals

By Thomas Warwick | January 20, 2022

Protein crystals are crucial for structure solution via X-ray crystallography but are notoriously hard to grow. We’ve got you covered with 5 clever protein crystallization seeding methods to grow impressive protein crystals.

A bearded man with a stained top holding stained laundry to convey protein staining methods

Protein Staining Methods: An Overview of 3 of the Best

By Thomas Warwick | January 12, 2022

There are several great protein staining methods, but how do you pick the one that’s appropriate to your intended application? Read on to find out.

An image of a thermal spring to depict the thermal shift assay.

Meltdown: A Hot Introduction to the Thermal Shift Assay

By Thomas Warwick | December 7, 2021

The interaction of proteins with ligands is an important phenomenon. Learn how to detect these interactions (and much more) using the thermal shift assay. In this article, we’ve got you covered with the basic theory and an easy protocol too.

An image of different types of salt to depict ways to distinguish between salt and protein crystals

5 Easy Ways to Tell Salt and Protein Crystals Apart

By Thomas Warwick | November 2, 2021

How do you make sure that the crystals you have grown are of your target protein? Can you tell salt and protein crystals apart without using X-ray diffraction? Yes, you can. Read on to discover five easy ways to distinguish between salt and protein crystals.

An image of a kid holding colorful pencils to depict using molecular visualization tools.

Learn to Draw a Molecule in PyMOL™ in 8 Easy Steps

By Thomas Warwick | September 16, 2021

Discover how to easily draw proteins and nucleic acids using molecular visualization tools with our step-by-step tutorial.

Image of teddy bears in bubbles as a funny wa to represent the need to remove excess detergent from membrane proteins

Beat Back the Bubbles: 6 Ways to Remove Excess Detergent from Your Membrane Protein Sample

By Thomas Warwick | August 26, 2021

Excess detergent in your membrane proteins samples can cause you serious headaches. We’ve got you covered with 6 ways you can remove excess detergent from membrane proteins.

An image of salt crystals to depict the crystallization of protein–DNA complexes

Crystallize Your Protein–DNA Complex by Optimizing These Key Parameters

By Thomas Warwick | July 27, 2021

Looking to engineer a crystal? Here are some key parameters to optimize to give you the maximum chance of success at crystallizing protein DNA–complexes.

An image of a man punching liquid to depict improving protein expression using osmotic shock

Improving the Expression of Insoluble and Inactive Proteins Using Osmotic Shock

By Thomas Warwick | July 6, 2021

Discover a better way to improve the expression of your insoluble and inactive proteins using osmotic shock.

Image of soap bubbles to represent working with membrane proteins

Working with Membrane Proteins: Tips for Expressing, Extracting, and Purifying Your Membrane Protein Sample

By Thomas Warwick | June 15, 2021

Working with membrane proteins can be tricky. Read on to get tried-and-tested tips and tricks for expressing, extracting, and purifying these water-phobic proteins.

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