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Human Dendritic Spine Analysis and Neurological Disorders
See the Hidden at Micron | Visualizing Organoid Complexity Through Advanced Imag
How to Optimize Your Pipetting Technique for Challenging Liquids
Measuring Antigen-specific Immune Responses at the Single-cell Level
Measuring Antigen-specific Immune Responses at the Single-cell Level
Democratizing Nanoscale Imaging at Molecular Resolution
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Writing, Publishing and Presenting
Using Scientific Animation to Present Complex Biological Mechanisms
Biological mechanisms are, by their nature, dynamic. They involve interaction, causality, and specific sequences that unfold over time. Standard scientific communication, however, tends to use static media that cannot represent time. This means that when you show a complex signalling pathway on a slide, your audience must first decode the spatial relationships, then infer the…
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The traditional career pathway for most scientists is to get a degree, a postdoc, and then a permanent position. But in the 21st century, a PhD no longer ensures security or a smooth career path. Your career plan is in your hands, and this means you must proactively control your professional identity. Two forces are challenging…
IC₅₀ and Kd are widely used in drug discovery, but they answer different questions. This article explains how to interpret IC₅₀ and Kd correctly, why they’re not directly comparable, and how combining both metrics leads to better compound prioritization and decision-making.
For decades, the diffraction of light has placed a hard limit on optical microscopy. Conventional widefield and confocal microscopes can’t resolve features smaller than about 200 nm laterally, which means critical signaling compartments and the nanoscopic organization of synapse-associated molecules remain hidden. The 21st century brought revolutionary super-resolution technologies, such as stimulated emission depletion (STED),…
To generate reliable quantitative bioluminescent data, you need more than a strong luciferase signal. Optimize bioluminescence assays for high-sensitivity detection by controlling substrate handling, timing, plate-reader settings, and normalization so technical noise doesn’t mask real biology. From luciferase and substrate choice to reader optimisation and in vivo bioluminescent imaging workflows, these practical strategies help you produce reproducible, interpretable data you can trust.
Microscopy & Imaging
For decades, the diffraction of light has placed a hard limit on optical microscopy. Conventional widefield and confocal microscopes can’t resolve features smaller than about 200 nm laterally, which means critical signaling compartments and the nanoscopic organization of synapse-associated molecules remain hidden. The 21st century brought revolutionary super-resolution technologies, such as stimulated emission depletion (STED),…
DNA / RNA Manipulation & Analysis
Unsure which next-generation sequencing (NGS) method to choose for your cancer and precision medicine research? Learn about the latest tools and tailored next-generation sequencing solutions for cancer research in this short guide.
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