Latest Events
Decoding Early Disease Risk Using Region-specific Genomics
Human Dendritic Spine Analysis and Neurological Disorders
See the Hidden at Micron | Visualizing Organoid Complexity Through Advanced Imag
On Demand Events
Advancing GxP-ready Microscopy: From Qualification to Data Integrity
Faster Single Cell Isolation for High-quality Cell Line Development
Integrated Software Solution for Analytical Development in the Biopharmaceutical
Advancing Precision and Control in EM Micro Target Preparation
Stop Forcing It: How to Make Progress Without Burning Out
Latest Articles
Expansion Microscopy: Achieving Nanoscale Resolution Using Conventional Fluorescence Microscopes
For decades, the diffraction of light has placed a hard limit on optical microscopy. Conventional widefield and confocal microscopes can’t resolve features smaller than about 200 nm laterally, which means critical signaling compartments and the nanoscopic organization of synapse-associated molecules remain hidden. The 21st century brought revolutionary super-resolution technologies, such as stimulated emission depletion (STED),…
Latest Podcasts
To generate reliable quantitative bioluminescent data, you need more than a strong luciferase signal. Optimize bioluminescence assays for high-sensitivity detection by controlling substrate handling, timing, plate-reader settings, and normalization so technical noise doesn’t mask real biology. From luciferase and substrate choice to reader optimisation and in vivo bioluminescent imaging workflows, these practical strategies help you produce reproducible, interpretable data you can trust.
Find out how to detect low-affinity protein binding without using SPR. The Octet® R8e BLI system bridges the gap between speed, simplicity, and sensitivity, transforming drug discovery workflows.
Mass photometry (MP) is a fast, label-free way to check protein oligomerization, heterogeneity, and complex formation using only ~10 µL of sample at 10–50 nM. It detects single molecules as they land on a glass coverslip, converts scattering contrast to molecular mass using standards (e.g., BSA), and outputs a histogram where peaks reveal monomers, dimers, higher oligomers, and aggregates with their relative abundance. MP supports quick go/no-go decisions and sample quality control before cryo-EM, crystallography, or binding studies. Good prep (clean coverslips, calibration, filtering/spinning, and ≥90–95% purity) keeps peaks sharp and interpretable. Know the limits: <30 kDa proteins and complexes may be missed.
Effective experimental design depends on choosing antibodies that match your target and assay conditions. This article explains how experimental optimization with recombinant antibodies and epitope mapping can improve consistency, reveal precise binding interactions, and support better reagent selection, enabling you to design assays that deliver more reliable, reproducible results.
Microscopy & Imaging
For decades, the diffraction of light has placed a hard limit on optical microscopy. Conventional widefield and confocal microscopes can’t resolve features smaller than about 200 nm laterally, which means critical signaling compartments and the nanoscopic organization of synapse-associated molecules remain hidden. The 21st century brought revolutionary super-resolution technologies, such as stimulated emission depletion (STED),…
DNA / RNA Manipulation & Analysis
Unsure which next-generation sequencing (NGS) method to choose for your cancer and precision medicine research? Learn about the latest tools and tailored next-generation sequencing solutions for cancer research in this short guide.
How-To Guides
Article Categories
- Analytical Chemistry & Chromatography Techniques
- Cells & Model Organisms
- Chemistry for Biologists
- Cloning & Expression
- DNA / RNA Manipulation & Analysis
- Flow Cytometry
- Genomics & Epigenetics
- Microscopy & Imaging
- PCR, qPCR & qRT-PCR
- Bioscience Mastery
- Basic Lab Skills & Know-how
- Career Development & Networking
- Dealing with Fellow Scientists
- Equipment Mastery & Hacks
- Getting Funded
- Lab Safety
- Lab Statistics & Math
- Organization & Productivity
