Join Us
Sign up for our feature-packed newsletter today to ensure you get the latest expert help and advice to level up your lab work.
Here we take a closer look at plasmid copy number and examine how it can be manipulated in the lab giving you flexibility in your work.
Cell confluency can affect cell behavior and growth. Find out what confluency is, how to measure it, and why it is a crucial consideration for your experiments.
NMR can generate tons of useful data for protein samples. Learn all about NMR and Protein Dimerization in this easy intro.
It pays dividends to think creatively about your research. Here are 8 tips to supercharge creativity in science and ensure a great environment to help your imagination flourish.
Understanding the basic (and simple!) chemistry behind DNA ligation will help you get better DNA ligation results. Learn all about it here.
NMR is a structural tool that plays second fiddle to crystallography. But there’s a cheap, label-free method of investigating protein folding by NMR.
Discover what phosphorylation is, understand why you might want to mimic it, and learn 3 ways to mimic phosphorylation for both in vitro and in vivo applications
Discover how embracing simplicity in science can make you a more effective researcher while reducing your workload.
Are you looking to improve your lab work, publication record, and grant success rate? Then read our guide to feedback—what it is, where it should come from, and how to give it to others.
You don’t have to be a genius to understand Cryo-EM. Discover the fundamentals of this powerful microscopy tool and what propelled it into the scientific mainstream.
The slow, inching progress of cryo-EM towards the scientific mainstream can be told as a story with three parts. So take a step back and enjoy a short history of cryo-electron microscopy.
You don’t have to be a brainbox to get your samples ready for cryo-EM, but a little wisdom goes a long way. Learn how to tend to your tissues, organize your organelles, and prepare your proteins to get the micrographs you’ve always dreamed of.
Microscopy is a huge and active field. Sometimes, it’s easy to forget the basics. Read our biologists’ guide to electron microscopy techniques.
It’s a tough reality, but research can be damaging to the environment. Discover our simple tips and do more sustainable research.
Microscopy is a huge and active field. Sometimes, it’s easy to forget the basics. Read our biologists’ intro to applications of electron microscopy.
Whether you’re generating, analyzing, or reviewing qPCR data you need to understand how it works and best practices. That’s why we’ve pulled together our top qPCR papers every researcher should read.
Are your plasmid preps giving your poor yields? We’ve got 11 reasons that might be causing it and how to fix them.
Organizing your files is simple with Zotero; we’ve got the lowdown on functionality, usability, and access.
The art of delegation can help save time and give you a happy, more productive lab life. Discover how with our easy guide to delegation for scientists.
We all rely on pH, pKa, and pI for a vast amount of our research. But what is pH? How does it relate to pKa and pI? Read the definitive guide.
Getting to know your protein’s structure can help uncover deeper insights and inspire new hypotheses. Discover how protein data bank files can help.
If you’re unsure as to how the peer-review process works, the difference between open and double-blind peer review or are wondering if peer review is broken, read on.
Why is SDS-PAGE run vertically? Agarose gel electrophoresis is run horizontally, so why not SDS-PAGE? Here are 3 great answers.
With the NanoDrop spectrophotometer, quantifying a DNA, RNA, or protein sample concentration is as easy. Here’s everything you need to know about the strengths and limitations of this handy spec.
Discover ways to perform total RNA extraction from TRIzol to kit-based and even old-school methods.
Circular dichroism is a type of spectroscopy that can tell you the type and percentage of secondary structure units in a protein sample. Here are 5 handy pointers on best circular dichroism practice to set up your experiment properly.
Getting science research grants is becoming increasingly competitive and difficult. Read our top tips to maximize your chances of success.
Circular dichroism is a type of spectroscopy that can tell you the type and percentage of secondary structure units in a protein sample. This article will take you through circular dichroism theory and some of its applications.
SDS-PAGE is the technique that unites life scientists. We all perform it during our research to separate protein analytes and, therefore, we all need a good SDS-PAGE gel recipe.
If you’ve worked in a lab, odds are you’ve had an encounter with filtration of one sort or another. Do you understand exactly how filters work, though? Or have you wondered why certain filters are used for certain lab applications?
Discover more about how ReadCube Papers can help you keep on top of your references.
Expressing your protein of interest but not sure if it’s properly folded or struggling with inclusion bodies? Read on to discover advice and tips for battling inclusion bodies and refolding proteins
There are several great protein staining methods, but how do you pick the one that’s appropriate to your intended application? Read on to find out.
Learn more about the key features of EndNote to work out if it’s the right reference manager for you.
Do you want to know about a cool way to detect and tell the difference between virus particles? Then read on to discover flow virometry!
Learn how Mendeley allows you to organize a library containing your favorite articles and generate citations and bibliographies while writing papers.
Discover more about biocuration, why it’s so important, and what it takes to become a biocurator. It turns out that biocuration as a career choice is easier than you might think!
This article reassesses the dangers of using ethidium bromide and compares some supposedly safer alternatives
Discover 6 critical scanning electron microscopy sample preparation points you need to know to get the best out of your SEM.
The interaction of proteins with ligands is an important phenomenon. Learn how to detect these interactions (and much more) using the thermal shift assay. In this article, we’ve got you covered with the basic theory and an easy protocol too.
The eBook with top tips from our Researcher community.