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Dive into the world of protein structure science, where AI is revolutionizing the field by offering accurate predictions and free, open-access tools. In this beginner’s guide, we’ll explore these groundbreaking tools, discuss their strengths and weaknesses, and examine the implications for traditional experimental methods like NMR and X-ray crystallography.
Struggling with your cloning? It could be time to try blunt-end cloning. This easy introduction explains what it is, when to use it, and how.
While using serum in cell culture can keep your cells healthy and happy, there are some notable downsides. We discuss the pros and cons of using serum in cell culture media and how to remove it if you want to eliminate it from your workflow.
You may be familiar with standard single fragment ligations, but did you know you can ligate multiple fragments into your vector all at the same time! Discover how to perform multiple fragment ligation, including the different methods and troubleshooting tips for when things go wrong.
Whether you’re generating, analyzing, or reviewing qPCR data you need to understand how it works and best practices. That’s why we’ve pulled together our top qPCR papers every researcher should read.
Discover more about biocuration, why it’s so important, and what it takes to become a biocurator. It turns out that biocuration as a career choice is easier than you might think!
We’re all familiar with DNA and RNA. But have you heard of xeno nucleic acids (XNAs)? Read on to find out how they can be applied in biological research, and how you can start using them in your experiments.
Discover what unnatural amino acids are, their applications, and how they can be used in your research in our beginner’s guide.
Deciding on the right peptide sequence can make or break your experiment. Find out what to keep in mind when designing a synthetic peptide.
Are you studying a small peptide or protein? Learn whether using synthetic peptides can save you hours of transfection, protein expression, and purification.
Want to reduce the use of antibiotics in the lab? Start with switching to alternative cloning methods that use alternative selection pressures.
Fret no more over fuzzy bands! We uncover how gradient gels can give you better results, and maximize your precious samples when performing SDS-PAGE
PubMed has had a makeover. Find out where your favorite features have moved to and what’s changed in this shiny new version.
When optimizing qPCR, you might try trial and error to improve your assay’s performance. Tweak this, tweak that, and the assay works better, right? Sometimes you might get lucky but adjusting single assay components interdependent with others is hardly systematic. You can spend a lot of time and resources hoping that this time, you will…
What Do We Mean by Diagnostic Sensitivity? In clinical diagnostics, questions about the sensitivity of an assay will inevitably surface. But what does “sensitivity” mean exactly? The lowest quantity of the given analyte that an assay can detect is often called sensitivity – and to be clear, this quantity is the analytical sensitivity or Limit…
When developing an assay, whether it is for basic research or for use in diagnostics, you will often be asked about your assay’s sensitivity. This is perhaps one of the most important performance characteristics you can determine for an assay, and in regulated work, such as in vitro diagnostic (IVD) development and clinical diagnostics, it…
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