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Are you preparing to run your first column chromatography experiment? Here are some basics that you should know before you use that precious sample.
Biological agents, including bacteria, viruses, parasites, and fungi, are categorized into four biosafety levels (BSL), each indicating a different threat level. These levels increase progressively, with level one organisms posing the least risk and level four the greatest. This article details each biosafety level, explaining their necessity and providing examples of organisms handled at each level.
This article explains a simple, 4-step method for automatic cell counting with ImageJ. Perfect for your cell proliferation studies, gene expression analysis, or whatever your downstream application might be.
Using ethanol precipitation to isolate or concentrate your nucleic acids? Find out how this routinely used technique works, and get tips to produce the best results.
Navigating the complexities of microbiome data visualization can be challenging. Our guide offers insights on selecting the right plots and optimizing them for maximum readability and publication readiness.
Tissue processing for histology is a key step between fixation and embedding. We take you through the steps of tissue processing in this simple guide.
Agar plates are the foundation of many experiments. Make sure your plates are perfect every time with these 8 tips and start your experiment ready for success!
Adherent cell fixation is a crucial step in preparing cells for microscopy and imaging, ensuring that cellular structures are preserved for detailed analysis. Read our 8-step guide on how to effectively fix adherent cells to your microscope slides, including tips on sterilization, coating, and fixation methods, right here.
Keep your lab’s freeze dryer running smoothly with our expert tips on care and maintenance, including oil changes and vacuum leak fixes.
Having trouble writing the discussion section for your scientific paper? Help is at hand. Read our do’s and don’ts to help you have your paper polished up in no time.
In-cell Westerns are a powerful technique that has enhanced how researchers analyze protein expression levels and signaling pathways within fixed cells. Learn about their primary advantages, applications, and some of the best tech and products to perform them.
Purified proteins must be kept soluble and active. Discover how to design the perfect protein purification buffer—from additives you can include and their appropriate concentrations to important considerations.
By removing the word ‘because’ from your vocabulary, you can gain a newfound sense of freedom, creativity, and authority in your decisions. Learn to make choices without justifications and experience the world with a fresh set of eyes.
Performing reproducible research is critical in science. This article discusses eight steps you can take to make your research more reproducible.
Do you prepare samples for electron microscopy and want to save time, money, effort, and frustration? This article provides hands-on advice to help you get the best possible data out of your EM experiments.
Dive into the world of protein structure science, where AI is revolutionizing the field by offering accurate predictions and free, open-access tools. In this beginner’s guide, we’ll explore these groundbreaking tools, discuss their strengths and weaknesses, and examine the implications for traditional experimental methods like NMR and X-ray crystallography.
Here’s your reliable and adaptable nuclear extraction protocol. It contains buffer recipes, explanations of what the reagents do, and top tips to boost yields.
Confused about yeast protein extraction methods? Let this article guide you through the process and help you select the most appropriate method based on your research goals and available resources.
The more expensive your lab centrifuge, the more sensitive and the easier it is to break. What can we do to give these pricey monsters a long, successful tenure in the lab? Read our 5 easy tips.
Want to know how to use a fume hood? Keep your head out of it for starters. Here are 10 extra tips to keep you safe when using one!
We all have patterns for tasks. While good patterns are helpful, bad ones can sabotage your career. Learn to identify and destroy harmful patterns.
It’s crucial that we stay safe in the lab. To prevent accidents, we should risk assess our work. So here’s how to conduct a risk assessment in 6 steps.
We all know acids are dangerous chemicals, and you should handle them carefully. But how should we handle bases? Read on for top tips for handling bases safely in the lab.
Learn the basics of how to passage cells in culture with this easy-to-follow guide. While the specifics change per cell line, the basics remain.
Not sure what we mean by cell passage number? Confused about how to calculate it? Wondering if there is a maximum number? We explain it all.
We often use size-exclusion chromatography to purify samples. Read this article to learn how to use it to measure sample molecular weight as well!
While using serum in cell culture can keep your cells healthy and happy, there are some notable downsides. We discuss the pros and cons of using serum in cell culture media and how to remove it if you want to eliminate it from your workflow.
Discover what RNA quality control is, why it’s so important for your experiments, and how to undertake it with these 3 key considerations.
We show you how to read a scientific paper efficiently to make the most of your reading time.
Journal Club. So much more than reading a paper aloud. So many ways to mess it up. Got to present one? Then read our journal club toolkit.
You may be familiar with standard single fragment ligations, but did you know you can ligate multiple fragments into your vector all at the same time! Discover how to perform multiple fragment ligation, including the different methods and troubleshooting tips for when things go wrong.
Contamination in your pipette can mean contamination in your experiments, making cleaning pipettes regularly critical. Here’s an easy guide on how to do it.
Got non-specific PCR amplification? You need touchdown PCR! Discover what it is, how it works, and get 5 top tips for performing touchdown PCR.
A neglected pH meter means less reliable experiments, poor reproducibility, and your time wasted. So, learn how to use a pH meter correctly!
Acids are common and essential chemicals in any research laboratory. In this article, you’ll get advice on how to handle strong acids safely to give you the confidence to routinely prepare, handle, and dispose of them in the lab.
I’d bet that your trusty pipette is probably one the the most often used tools in the lab. But do you have any idea how to check the accuracy of your pipette? We’ll take you though how to do this in just 7 easy steps.
Can’t be bothered doing a qPCR standard curve? Find out why it’s important to getting great results and how to do it.
NMR is a powerful structural tool for studying proteins. Learn how to use multidimensional NMR to identify ligand binding sites and more!
Here we take a closer look at plasmid copy number and examine how it can be manipulated in the lab giving you flexibility in your work.
Cell confluency can affect cell behavior and growth. Find out what confluency is, how to measure it, and why it is a crucial consideration for your experiments.
The eBook with top tips from our Researcher community.