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The Importance of Metabolomics Research

Metabolomics may sound like a fictional character in the famous comic series “Asterix”, but it is very important in understanding systems biology and in clinical research against various...
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Article

6 Career Building Steps to Take While in Graduate School

You chose a great lab in a great graduate program, you work around the clock to get data, you know the literature like the back of your hand, and you have regular meetings with your boss to assess your...
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Article

Faster PCR Optimization

So, you’ve designed PCR primers to amplify your sequence of interest, and you’re ready to go.  But unless you have a never-ending supply of template, polymerase, and a thermocycler with a gradient...
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Scientific Conferences: What to Expect Other Than Lectures and Coffee?

Ever wanted to go to a conference, but don’t know what to expect, which one to go to, or how to even begin to ask your boss to let you attend a conference? Look no further! I have some suggestions on how...
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Article

Multiplex Cytometric Bead Array: The ABCs of CBAs

Multi-parameter data acquisition is key to the modern era of science research. I, for one, wish every single experiment that I design would give me the maximum amount of information. For example, in cell...
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Article

AAV Production Part II: Virus Purification

In Part I of AAV Production, I described how to produce crude (non-purified) AAV. In this article, I am going to tell you how to purify that crude prep. Virus purification is usually done by gradient...
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Article

Transitioning out of the Lab: B­­­­reaking up Is Hard to Do

Working in a research lab is not a normal job. The hours are often unconventional and the tasks can run from exciting to mundane—it’s a world all of its own. Even so, your loyalty to your field and people...
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Article

How to Dephsophorylate DNA Using Calf Intestinal Phosphatase

When you dephosphorylate a vector for cloning, you remove the 5' phosphate groups required by DNA ligase to join the phosphodiester DNA backbone together. This prevents your vector from ligating back to itself...
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Article

Pre-Analytical Sample Handling: What Can You Do Better?

If you study human disease, you will likely handle a pre-analytical sample or two (or hundreds).  For example, you could handle whole blood, serum or plasma, tissue biopsies, urine, fecal samples,...
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Critical Factors for Full Characterization of Biosimilars

Today, about half of all therapeutic drug approvals by the US Food and Drug Administration (FDA) are for biological drugs. That number is expected to rise to 75 percent by 2025. When these biologics come off...
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