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Article

How to Cheat QuikChange™

Generating a DNA vector library of single and/or compound mutants for a target protein can be a daunting task. If you’re lucky and work in a well-funded lab, you might outsource this process via gene...
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Article

Practical Secrets of the Bacterial World for the Uninitiated

As a protein biochemist where bacteria were mere work horses, imagine my surprise when I began work in a bonafide micro lab! I discovered that bacteria could be much fussier than my good ol’ cloning and...
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Article

Introducing Aptamers for Super Resolution Microscopy

What do you use if antibodies are too large for super resolution microscopy? Aptamers. These are small affinity reagents (~ 2 nm!) that interact with their target in the same way as an antibody, but without the hefty backbone attached.
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Article

Learn from Microbes: Tips for a Postdoc Transition

This article is not about adaptive laboratory evolution of your model organism. It is about your adaptive laboratory evolution. We could take a few tips from bacteria to survive in fluctuating conditions of the lab and have a successful post transition.
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Article

Mysterious Plant miRNAs: What About Them?

Welcome to the last article in this series! Last, but by no means least, we will look at the importance of plant miRNAs and how they differ from their animal counterparts. When/How Were Plant miRNAs...
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Commercial Blog

Decoding the Genome: Applications of DNA Sequencing

The age of sequencing is undoubtedly upon us. From improving cancer diagnostics to pinning down elephant poaching hotspots, DNA sequencing is revolutionizing the world around us from the ground up. The latest...
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Article

Reducing Lab Waste One Experiment at a Time

As a scientist myself, I have always been focused on performing experiments to achieve my sole goal of producing data for a publication. Recently I started paying attention to the waste I solely generate on a...
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Article

Using PubCrawler: How to Speed Up Your Literature Searches by Crawling

It often seems like a full-time job searching PubMed for the latest papers on adult neurogenesis, mutations in kinase genes that lead to cancer, or the newest papers published from a major figure in your field....
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Article

Staying Ahead of the Pack in Undergraduate Research

Whether you’re just beginning, or nearing the end of your undergraduate career, getting involved in research can be overwhelming and stressful. There are many factors to consider, so keep it simple and focus...
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Article

Hot, Frozen, Sublimed And Blown: Sample Storage Methods Summarized – Part Two

In part one, I discussed the ‘how to’ of simply freezing samples and the basics of vacuum evaporation, often referred to as speed vacing. Now, we’ll have a look at two more complex sample storage...
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