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Nuclear Extraction: Protocol Mysteries Revealed!

Have you ever bought a kit from a biotechnology company and followed the instructions… only to realize you’re not even sure why you’re doing certain steps in the prescribed way? I usually use a...
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Article

Gateway to the Cellular Kingdom: Cell Fixation and Permeabilization Techniques

One of the much sought after question asked by many researchers worldwide is – “What is the gene expression profile of a single cell within a heterogenous pool of cells?” While mass cytometry is the...
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Commercial Blog

For Long-Read Sequencers, Size Selection Is Key

It took scientists a little while to warm up to long-read sequencing, but now you couldn’t pry most of them away from their sequencers with a crowbar. Long reads — we’re talking 10,000 bases and more —...
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Article

How to Cheat QuikChange™

Generating a DNA vector library of single and/or compound mutants for a target protein can be a daunting task. If you’re lucky and work in a well-funded lab, you might outsource this process via gene...
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Article

Practical Secrets of the Bacterial World for the Uninitiated

As a protein biochemist where bacteria were mere work horses, imagine my surprise when I began work in a bonafide micro lab! I discovered that bacteria could be much fussier than my good ol’ cloning and...
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Article

Learn from Microbes: Tips for a Postdoc Transition

This article is not about adaptive laboratory evolution of your model organism. It is about your adaptive laboratory evolution. We could take a few tips from bacteria to survive in fluctuating conditions of the lab and have a successful post transition.
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Article

Introducing Aptamers for Super Resolution Microscopy

What do you use if antibodies are too large for super resolution microscopy? Aptamers. These are small affinity reagents (~ 2 nm!) that interact with their target in the same way as an antibody, but without the hefty backbone attached.
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Article

Mysterious Plant miRNAs: What About Them?

Welcome to the last article in this series! Last, but by no means least, we will look at the importance of plant miRNAs and how they differ from their animal counterparts. When/How Were Plant miRNAs...
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Commercial Blog

Decoding the Genome: Applications of DNA Sequencing

The age of sequencing is undoubtedly upon us. From improving cancer diagnostics to pinning down elephant poaching hotspots, DNA sequencing is revolutionizing the world around us from the ground up. The latest...
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Article

Reducing Lab Waste One Experiment at a Time

As a scientist myself, I have always been focused on performing experiments to achieve my sole goal of producing data for a publication. Recently I started paying attention to the waste I solely generate on a...
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