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How To Optimize Bioluminescence Assays for High-sensitivity Detection
To generate reliable quantitative bioluminescent data, you need more than a strong luciferase signal. Optimize bioluminescence assays for high-sensitivity detection by controlling substrate handling, timing, plate-reader settings, and normalization so technical noise doesn’t mask real biology. From luciferase and substrate choice to reader optimisation and in vivo bioluminescent imaging workflows, these practical strategies help you produce reproducible, interpretable data you can trust.
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Find out how to detect low-affinity protein binding without using SPR. The Octet® R8e BLI system bridges the gap between speed, simplicity, and sensitivity, transforming drug discovery workflows.
Mass photometry (MP) is a fast, label-free way to check protein oligomerization, heterogeneity, and complex formation using only ~10 µL of sample at 10–50 nM. It detects single molecules as they land on a glass coverslip, converts scattering contrast to molecular mass using standards (e.g., BSA), and outputs a histogram where peaks reveal monomers, dimers, higher oligomers, and aggregates with their relative abundance. MP supports quick go/no-go decisions and sample quality control before cryo-EM, crystallography, or binding studies. Good prep (clean coverslips, calibration, filtering/spinning, and ≥90–95% purity) keeps peaks sharp and interpretable. Know the limits: <30 kDa proteins and complexes may be missed.
Effective experimental design depends on choosing antibodies that match your target and assay conditions. This article explains how experimental optimization with recombinant antibodies and epitope mapping can improve consistency, reveal precise binding interactions, and support better reagent selection, enabling you to design assays that deliver more reliable, reproducible results.
Murine bone marrow derived dendritic cells (BMDCs) are one of the easiest primary cell cultures to generate. The beauty lies in the fact that in the end you have a large quantity of robust DCs that can be matured and used to study a variety of DC functions and DC-T-cell interactions. But there are a…
Microscopy & Imaging
Mass photometry (MP) is a fast, label-free way to check protein oligomerization, heterogeneity, and complex formation using only ~10 µL of sample at 10–50 nM. It detects single molecules as they land on a glass coverslip, converts scattering contrast to molecular mass using standards (e.g., BSA), and outputs a histogram where peaks reveal monomers, dimers, higher oligomers, and aggregates with their relative abundance. MP supports quick go/no-go decisions and sample quality control before cryo-EM, crystallography, or binding studies. Good prep (clean coverslips, calibration, filtering/spinning, and ≥90–95% purity) keeps peaks sharp and interpretable. Know the limits: <30 kDa proteins and complexes may be missed.
DNA / RNA Manipulation & Analysis
Unsure which next-generation sequencing (NGS) method to choose for your cancer and precision medicine research? Learn about the latest tools and tailored next-generation sequencing solutions for cancer research in this short guide.
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