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Re-Think PCR and Win an IPhone

Robert, a Bitesize Bio reader sent me an e-mail to tip me off about a fun little contest being run by BioRad at www.rethinkpcr.com. You are invited to say how you would "re-think" PCR. At first I thought...
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Gene Regulatory Networks during Development

Gene regulatory network (GRN) circuits are collections of DNA segments in a cell which interact with each other (indirectly through their RNA and protein expression products) and with other substances in the...
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10 Reasons NOT to be a Scientist

Ok, this week has been a bad week in the lab so far. A few weeks ago I wrote a post describing 15 reasons to be a scientist. Today I am in the mood to cross over to the dark side and give you 10 reasons NOT to...
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A Missing Post-translational Modification

Eukaryotic cells possess a surveillance mechanisms that identifies aberrantly processed mRNA precursors and prevents their flow to the cytoplasm by tethering them near the site of transcription. Termed...
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Spare a Thought for Tech Support Reps

Have you ever called technical service departments for advice and help in troubleshooting or choosing a product? Depending on the reason for the call, the experience can vary from positive and helpful all the...
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History of Cell Biology

The cell theory, or cell doctrine, states that all organisms are composed of similar units of organization, called cells. The concept was formally articulated in 1839 by Schleiden & Schwann and has remained...
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Around the Blogs

Here's what I've been reading around the blogs this week... The Seven Stones blog had an insightful article contrasting the rise of human genetics with James Watson's sad fall from grace. The article...
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Fluorescent Neurons Over the Brainbow

Site-specific recombinases have, for the past 20 years, been one of the most powerful tools in studying the functions of all sorts of genes. Most widely used as the Cre/lox-based system for inserting or...
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Ubiquitination Isn’t Just for Recycling Anymore

Ubiquitin is a small protein, which can be attached to other cellular proteins - a post-translational modification called ubiquitination. Discoveries in the '80s illuminated ubiquitin as a label for...
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Cells – This Side Up

Perhaps the most fundamental aspect of migration of any kind is, how do you know which way to point yourself? Heck, this isn't just about migration, it's about how something is oriented in its immediate...
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