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T cells can be tricky to engineer with CRISPR. Find out the key considerations when editing these cells and how you can overcome any associated challenges.
While CRISPR offers vast applications in disease research and drug target identification, it’s not always the optimal choice for every scenario. Explore the main advantages and challenges of using CRISPR-Cas9 to determine if it’s the right fit for your project.
Learn how the CRISPR prokaryote immune response systems were first discovered and the development of the CRISPR-Cas9 gene-editing tool.
Investigating human diseases and genetic variation is complex, but CRISPR-edited induced pluripotent stem cells present a promising alternative to immortalized cell lines. This article delves into genome editing principles and offers practical steps for optimizing research techniques, ensuring more accurate and ethical studies.
Designing Cas13 gRNAs is a bit different from the standard Cas9. Read this guide to learn how it differs, and get a step-by-step guide on designing the perfect Cas13 gRNAs.
CRISPR isn’t just about DNA editing. Discover how you can use Cas13 proteins in your research to knock down, modify or track RNAs in mammalian cells.
If you need a multi-gene knockout or large-scale genomic modification, or want reduced off-target effects, then multiplex CRISPR is for you!
Discover two CRISPR-based viral diagnostic strategies, DETECTR and SHERLOCK.
Discover how to get started with CRISPR gene editing in your experiments with our key considerations.
Want to do some epigenome editing? Discover the usefulness of catalytically inactive (dead) Cas9.
CRISPRa allows you to activate or overexpress genes in a more endogenous manner. Find out the steps to getting started.
Level-up your troubleshooting ability by determining the success of failure of each stage of your CRISPR experiment.
Designing a CRISPR experiment can be daunting. We’ve got tips and pointers to help you get off on the right foot.
Read up on the various methods for delivering CRISPR reagents and how to choose between them.
Grab an overview of CRISPR technology from its roots as a bacterial defense system to how it can be utilized in health and research.
Get some ideas on what CRISPR can do for you and what using it involves.
After you’ve generated your mutuations using CRISPR-Cas, the next step is to identify those cells that have been successfully edited. There are a few different ways to check for the mutations. I’m going to discuss some of the more popular ones.
The development of CRISPR/Cas9 technology has made it relatively straightforward to selectively edit genomes and has revolutionized the way in which we approach biological questions. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats and in simple terms, this technique allows you to direct a nuclease to cut at a specific site in the genome of interest. The…
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