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Latest Articles
Microscopy and Imaging | Protein Expression and Analysis
Mass Photometry: An Easy Way to Determine Protein Oligomerization and Heterogeneity
Mass photometry (MP) is a fast, label-free way to check protein oligomerization, heterogeneity, and complex formation using only ~10 µL of sample at 10–50 nM. It detects single molecules as they land on a glass coverslip, converts scattering contrast to molecular mass using standards (e.g., BSA), and outputs a histogram where peaks reveal monomers, dimers, higher oligomers, and aggregates with their relative abundance. MP supports quick go/no-go decisions and sample quality control before cryo-EM, crystallography, or binding studies. Good prep (clean coverslips, calibration, filtering/spinning, and ≥90–95% purity) keeps peaks sharp and interpretable. Know the limits: <30 kDa proteins and complexes may be missed.
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Effective experimental design depends on choosing antibodies that match your target and assay conditions. This article explains how experimental optimization with recombinant antibodies and epitope mapping can improve consistency, reveal precise binding interactions, and support better reagent selection, enabling you to design assays that deliver more reliable, reproducible results.
Murine bone marrow derived dendritic cells (BMDCs) are one of the easiest primary cell cultures to generate. The beauty lies in the fact that in the end you have a large quantity of robust DCs that can be matured and used to study a variety of DC functions and DC-T-cell interactions. But there are a…
Gel and blot imaging has come a long way. Film gave you sensitivity but slowed you down with darkrooms and inconsistent results. Camera systems sped things up but still left you fighting noise and limited dynamic range. Laser imaging now gives you cleaner signals, sharper focus, and far more flexibility across sample types.
Peptide-based droplets offer a simple, reproducible, and lipid-free way to transfect difficult cells such as iPSCs and primary cells. By skipping lipids, solvents, and cold-chain requirements, these methods reduce toxicity, batch variability, and workflow complexity—opening the door to more reliable gene delivery in your most sensitive cell types.
Microscopy & Imaging
Mass photometry (MP) is a fast, label-free way to check protein oligomerization, heterogeneity, and complex formation using only ~10 µL of sample at 10–50 nM. It detects single molecules as they land on a glass coverslip, converts scattering contrast to molecular mass using standards (e.g., BSA), and outputs a histogram where peaks reveal monomers, dimers, higher oligomers, and aggregates with their relative abundance. MP supports quick go/no-go decisions and sample quality control before cryo-EM, crystallography, or binding studies. Good prep (clean coverslips, calibration, filtering/spinning, and ≥90–95% purity) keeps peaks sharp and interpretable. Know the limits: <30 kDa proteins and complexes may be missed.
DNA / RNA Manipulation & Analysis
Unsure which next-generation sequencing (NGS) method to choose for your cancer and precision medicine research? Learn about the latest tools and tailored next-generation sequencing solutions for cancer research in this short guide.
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