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Have a healthy respect for the ultra! Here are some hints and tips for using a preparative ultracentrifuge, disaster free.
While almost all of you are probably familiar with the power of eBay to bring you everything from concert tickets to electronics to your very own Batmobile, you may not have realized that the world’s largest garage sale also has quite a collection of laboratory equipment. I’ve been turning to this source for equipment for…
While reading my back issues of Applied and Environmental Microbiology (AEM), I came across an interesting paper that detailed an in-depth study on the effectiveness of hand cleaners to remove Norwalk virus (NV) from intentionally contaminated hands. Yes that’s right – intentionally contaminated, and how. The study volunteers allowed a 20% stool suspension containing Norwalk virus to be…
Graduate school (PhD training) is full of roadblocks and obstacles that threaten to hinder progress, but your major professor (PI) should not be one of them. If you are frustrated with your progress and your lab environment has become unbearable, don’t throw in the towel just yet! You may need to change labs. Finding the…
We recently had a feature from Jode on everyday equipment that you can use in the lab, but what about the other way around? Do you ever take a look at what you’re doing in the lab and think, “Wow, this would really come in handy at home?” Here are a few of the things…
Reading papers on-screen is not something that everyone likes but if you can get used to it, it will help save you time and paper and make filing your literature a breeze. If you use a wide flatscreen monitor, something that is 17inch or bigger, then this tip could make your on-screen reading more pleasurable….
The release of the iPad this week may bring the long-expected replacement of the paper-bound lab notebook by electronic notebooks one step closer. But are scientists, particularly PIs, comfortable with electronic lab notebooks? The rise of the tabletsThe concept of an electronic lab notebook isn’t anything new, and even the idea of implementing it on…
In an ideal world, every PI would be a nurturing and challenging mentor who carefully guides your project and is invested in developing your skills as a scientist. In the real world, however, that kind of leadership can be hard to find. In any case, one of the most important and useful mental steps you…
A recent article published by The Scientist called Power Couples gave advice and examples for scientist couples who have successfully balanced their life at home and in the lab. It was interesting from the perspective of how two very busy and career motivated people work together to have it all: raise a family, run a lab, and stay in love…
Find out how to build a plate centrifuge using a salad spinner. Gathering the components is as complicated as it gets!
Presenting your work is a fantastic opportunity to get feedback on your project, demonstrate the significance of your results, and make the connections that will enhance your future career. And yet, how many incomprehensible lab meetings have we all sat through? How many seminars have you attended that left you feeling more confused than inspired?…
How often do you make errors in the lab that ruin a good experiment? Rather than flaws in experimental design, I mean errors like forgetting to add a reagent, pipetting the wrong amount, or following a protocol step wrongly. Especially early on in your career, errors like this can be a real drain on your…
My PhD was a soul-less affair. It was also rock-less, jazz-less and pop-less. And all because my supervisor was of the opinion that music in the lab was a distraction that reduced concentration and our ability to do the job. “Rubbish!”, I thought, “Nothing helps you through a mindless task like splitting cells, pipetting or…
In a previous article, I listed some ways that people annoy their co-workers and many of you added some of your own pet peeves. Now I would like to discuss some ways to be the lab favorite, also known as the “golden child”. Does your lab have a “golden child”? Someone who is always perfect,…
You youngsters don’t know how easy you’ve got it. Kits, outsourcing and improved practices are making research easier and easier. At least in theory (who are we kidding?). In the old days things were much tougher, and many wiley old scientists bear the scars, mental and physical, of carrying out techniques that were mind numbing,…
After Peter’s Introduction to Linux, those of you brave enough to accept the challenge will now have Linux installed on your machine so today I want to highlight to you some of the wonderful free software that is available for biologists using Linux. Before I start, I should mention that virtually all tools of modern…
A couple of weeks ago, Nick tried to convince us that we should all be using Macs. But why would you want to use a Mac (or a PC) when you could have an operating system that: That operating system is Linux. And I think that it is high time that more bioscientists got to…
So you finally got your PhD (or your masters or batchelor’s) and you are making the big switch to a small biotech company. You will probably have been hired for the specific skill set that you have built during your training, but now you have to learn to apply those skills to solve real world,…
If you ask any finished graduate student, most of us starting a Masters or PhD program were very excited at what awaited us and if you were anything like me, you were foolishly idealistic and thought you were going to pull on a lab coat, cure cancer and save the world. Ok, maybe most people…
Criticism is not just valuable, it is essential for a person’s development as a scientist, or anything else for that matter. Well that’s not entirely true. Not all criticism is valuable, it has to be the right kind of criticism. It has to be constructive and better still, well delivered in order to inspire the…
Rushing and overloading yourself in science is common, even normal. Surprisingly it is considered as an admirable aspect of “scientific flair” in some quarters. And the sad fact is that it is an ingrained part of the scientific landscape. But is this the best way to do things? Should you allow yourself to succumb and…
Really great presentation skills. Some people in science seem to have them, and some don’t. I am one of the don’ts. Sure, I can get up in front of people and talk when needed, but it won’t be a polished performance by any means. I can get my message across but my delivery is not…
Keeping safe in the lab really only requires one thing: common sense. But if you look at what people are doing in the lab, you might think that common sense isn’t so common after all. What are the most stupid things you have seen people do in the lab to put the safety of themselves…
As well as having had some negative work experiences, I’ve also had the pleasure of working with some wonderful people, including some of my previous bosses. Life is too short to deal with some of the idiosyncrasies described in Suzanne’s previous article on bad bosses.So let’s balance the scale and look at what it takes…
Now that you know who you are trying to impress with your resume, it’s time to focus on how it looks and reads. Remember,.this is NOT the venue to display your creativity. They key is to keep it simple and clear. Follow a simple format that is easy to read – remember that your audience…
Going to conferences normally involves a significant investment of time and money. So it’s important to get as much as you can out of them. One of the most valuable things you can get from a conference is contacts. These can build into a network of people that will be valuable to you throughout your…
RPM and RCF are two units that can be used to describe the speed of a centrifuge. Although they may look similar, they are oh-so-different and confusing them has resulted a disastrous end to many an experiment. So let’s set it out in black and white to make sure you don’t succumb to the same…
If you search the literature using a comprehensive search engine like Google Scholar, you will get several types of articles listed. Most of them are peer reviewed journal articles and many are patents. But beware of an important distinction between the two: Although patents can contain useful information, they are not authoritative because they are not…
Looking for cheaper or faster solutions in the lab? Here’s our top 10 list of ways to use everyday items to make gadgets and for low-tech solutions for the lab.
Undergrad courses teach you to learn in a specific way. You have to cram in as much information into your brain as possible, hold it in there, then regurgitate as much of it as possible on exam day. Of course, actually understanding what you are talking about, and working from basic principles, helps but the…
No scientist is an island, not even a great scientist like you. A good network of professional contacts is as essential to your career as hard work at the bench. This is because your network can open many doors that no amount of good bench work could. Access to unpublished information, collaborations and job opportunities…
Heat maps are a useful way to represent certain types of data; the data are colored by coloring according to the values in them, (e.g. red for high values, yellow for medium and green for low values), providing a powerful visual representation of a data set. This allows you to quickly see results from DNA…
PapersIn recognition of a fresh new year and a fresh new direction for Bitesize Bio, I thought I’d start my tenure as the fresh new Bioinformatics “guru” by introducing you to a handful of websites that will help you locate established as well as fresh new and (mostly) free online molecular biology and bioinformatics databases…
Everyone is worried about getting results, aren’t they? Results are what you need for success in science – they are essential for bringing the funding in. But focusing on results per se is not a good way to work because, as a scientist, you can’t “get” results. You can’t “make” them happen. Essentially in every…
In my current position, I had the opportunity to hire a new R&D scientist to join the team. I was excited at being able to build my team and take my time to find the perfect fit for our company. My experience in the process of hiring gave me a new perspective on all the…
Calculating your fudge ratio can help you get your work done on time and get home before dark. Here’s how.
Biology researchers have a bad habit of doing accurate assays using semi-accurate tools. Here are some suggestions on how to sharpen up the accuracy of your assays.
You probably use and rely them more than any other tool in the lab, but just how accurate are your pipettes?
As far as your lab work is concerned, your lab book is the source of all knowledge. Making it easy to find things in there will help. Here’s how to do it.
Bioscientists are generally nature-lovers at heart, but the average bio lab is incredibly wasteful. Here are some ways to reduce your lab’s environmental impact.
The eBook with top tips from our Researcher community.