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Making 3D Live Imaging Practical and Scalable with Viventis SCAPE
Plasma FIB Comes of Age: Expanding Volume EM & Cryo Workflows
Capturing Fast Biological Dynamics in Real Time with Viventis SCAPE
Automated Cell Counting and Pathology Mapping Across the Whole Brain
Simultaneous Human and Mouse Cytokine Profiling in Humanized Immune System Mouse
The Versatility of Advanced Confocal Microscopy for Complex Biological Samples
Reducing Lab Energy Waste: Real Steps, Real Savings
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Latest Articles
Going Serum-Free? A Practical Guide to FBS-Free Culture
You’ve moved your cells into serum-free medium and they look sparse and sad. Whatever pushed you to drop fetal bovine serum the temptation now is to blame the medium and start reformulating. But before you spend any more of your precious grant money, read this article.
When buying antibodies, it’s crucial to verify the true source and validation of the reagent rather than relying on brand names alone. In this article, I’ll explain how to check clone details, application-specific evidence, lot numbers, and supplier accountability to avoid costly failures and ensure better reproducibility.
Onboarding Empower™ Users is most effective when training focuses first on core terminology, compliance, and daily workflows using your lab’s real data. Teaching less initially builds a solid foundation, enabling quicker, confident analyst independence. Competence, not time, should guide when to expand training to advanced topics.
You don’t have the time to read every paper, so stop trying! Here’s how I decide whether a paper has earned my attention: I break-up the paper into sections, then evaluate the main claim, compare the discussion with the introduction, turn the results into closed questions, and, finally, critically assess the controls. Here’s how you can do the same.
If your drug discovery research keeps failing human trials, the issue may be your hypothesis. These questions will help you design a more clinically relevant study before running it. Drawing from my experience in optometry, basic research, and clinical work focused on infectious keratitis, I’ll share how you can make your research more translational.
Microscopy & Imaging
Optical microscopy has always been restricted by the diffraction of light. Because conventional widefield and confocal microscopes cannot resolve structures substantially smaller than about 200nm laterally, they miss critical signaling compartments and nanoscopic organization. Newer super-resolution technologies, such as stimulated emission depletion (STED), structured illumination microscopy (SIM), and photoactivated localization microscopy (PALM), solve this problem…
DNA / RNA Manipulation & Analysis
Transcriptome–Methylome Integration often fails due to structural issues rather than biological absence. Key challenges include over-aggregation of CpG sites, variance mismatches, asymmetric data preprocessing, and inappropriate statistical models. Proper region mapping, variance assessment, covariate alignment, and cohort size evaluation are essential to detect true regulatory relationships. Addressing these factors before complex modeling improves interpretation and avoids false conclusions about methylation-expression associations.
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