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Organoid Meet-up: Methods in Organoid Development
Capturing Fast Biological Dynamics in Real Time with Viventis SCAPE
Automated Cell Counting and Pathology Mapping Across the Whole Brain
Simultaneous Human and Mouse Cytokine Profiling in Humanized Immune System Mouse
Unmasking Extramedullary Multiple Myeloma: Spatial Profiling of Plasma Cells
Career by Design, Not by Default: Lessons from 20 Years in Life Sciences
The Versatility of Advanced Confocal Microscopy for Complex Biological Samples
Reducing Lab Energy Waste: Real Steps, Real Savings
Latest Articles
How to Run a Successful Stem Cell Differentiation Assay
Stem cell differentiation is central to disease modelling, drug discovery, and developmental research. Learn how differentiation works, how to choose the right culture system, support cells through lineage commitment, and confirm that differentiation has succeeded. This practical guide covers key considerations for 2D and 3D models, validation methods, and downstream applications in the lab.
Your grants are submitted, your experiments are running, and your next paper is paper is nearly ready…and you’re exhausted! But maybe you don’t have too much work. Maybe you have too many windows open in your mind’s browser. Here’s four rules to help you manage your lab projects, and getting through the day with more ease.
Learn how to create clear procurement records that track what was ordered, what arrived, the documentation included, and any problems encountered. These six simple steps will help you stay organized in the lab and reduce the need for you to rely on memory alone.
UV-Vis measures all molecules that absorb at 260 nm, while fluorescence assays mainly detect the target nucleic acid selected by the dye. Compare both values alongside A260/A280 and A260/A230 ratios to identify contamination, low-concentration measurement limits, or handling errors. Agreement between the methods indicates confidence in the sample results, while a consistent gap helps you decide whether to repurify, adjust input, or use a more sensitive method.
Preparing a manuscript involves plenty of work beyond writing: author lists, affiliations, disclosures, funding statements, references, and figure preparation. This post covers the tools I use to handle that admin, why I choose them over AI, and how they help. If you’re first author on a multi-author paper, this is for you.
Microscopy & Imaging
Optical microscopy has always been restricted by the diffraction of light. Because conventional widefield and confocal microscopes cannot resolve structures substantially smaller than about 200nm laterally, they miss critical signaling compartments and nanoscopic organization. Newer super-resolution technologies, such as stimulated emission depletion (STED), structured illumination microscopy (SIM), and photoactivated localization microscopy (PALM), solve this problem…
DNA / RNA Manipulation & Analysis
UV-Vis measures all molecules that absorb at 260 nm, while fluorescence assays mainly detect the target nucleic acid selected by the dye. Compare both values alongside A260/A280 and A260/A230 ratios to identify contamination, low-concentration measurement limits, or handling errors. Agreement between the methods indicates confidence in the sample results, while a consistent gap helps you decide whether to repurify, adjust input, or use a more sensitive method.
How-To Guides
Article Categories
- Analytical Chemistry & Chromatography Techniques
- Cells & Model Organisms
- Chemistry for Biologists
- Cloning & Expression
- DNA / RNA Manipulation & Analysis
- Flow Cytometry
- Genomics & Epigenetics
- Microscopy & Imaging
- PCR, qPCR & qRT-PCR
- Bioscience Mastery
- Basic Lab Skills & Know-how
- Career Development & Networking
- Dealing with Fellow Scientists
- Equipment Mastery & Hacks
- Getting Funded
- Lab Safety
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- Organization & Productivity
