Latest Events
Choosing Your Next Confocal: What Experts Look For—and Why It Matters
Surviving, Thriving, and Advancing Your Career... While Enjoying Yourself
Illuminating Nanomaterial–Cell Interactions by Confocal Microscopy
On Demand Events
Using Integrative Spatial Biology to Study the Mouse Brain
Applying Cell Sorting in Clinical Immunology Research
Democratizing Nanoscale Imaging at Molecular Resolution
Human Dendritic Spine Analysis and Neurological Disorders
Decoding Early Disease Risk Using Region-specific Genomics
Latest Articles
qPCR or RNA-seq for DGE studies: How 3’ end counting eliminates the compromise between speed and scale
Choosing between qPCR or RNA-seq often means balancing speed and scope. qPCR is quick but limited to a small set of pre-selected genes, while RNA-seq offers a full transcriptome view but you typically wait weeks to get results. This article explores how 3′ RNA-seq bridges that gap, delivering genome-wide insights in days.
Latest Podcasts
Find out how to detect low-affinity protein binding without using SPR. The Octet® R8e BLI system bridges the gap between speed, simplicity, and sensitivity, transforming drug discovery workflows.
Biological mechanisms are, by their nature, dynamic. They involve interaction, causality, and specific sequences that unfold over time. Standard scientific communication, however, tends to use static media that cannot represent time. This means that when you show a complex signalling pathway on a slide, your audience must first decode the spatial relationships, then infer the…
Gel and blot imaging has come a long way. Film gave you sensitivity but slowed you down with darkrooms and inconsistent results. Camera systems sped things up but still left you fighting noise and limited dynamic range. Laser imaging now gives you cleaner signals, sharper focus, and far more flexibility across sample types.
When interpreting cellular metabolism assays, focusing on single pathways can be misleading, as metabolism operates as a connected network. Metabolites such as pyruvate, malate, glycogen, branched-chain amino acids, and β-hydroxybutyrate sit at key metabolic crossroads, where changes reflect shifts in energy routing, redox balance, and stress adaptation. Understanding these junctions helps you evaluate metabolic data more accurately and design experiments that capture the true cellular state.
Microscopy & Imaging
Optical microscopy has always been restricted by the diffraction of light. Because conventional widefield and confocal microscopes cannot resolve structures substantially smaller than about 200nm laterally, they miss critical signaling compartments and nanoscopic organization. Newer super-resolution technologies, such as stimulated emission depletion (STED), structured illumination microscopy (SIM), and photoactivated localization microscopy (PALM), solve this problem…
DNA / RNA Manipulation & Analysis
Unsure which next-generation sequencing (NGS) method to choose for your cancer and precision medicine research? Learn about the latest tools and tailored next-generation sequencing solutions for cancer research in this short guide.
How-To Guides
Article Categories
- Analytical Chemistry & Chromatography Techniques
- Cells & Model Organisms
- Chemistry for Biologists
- Cloning & Expression
- DNA / RNA Manipulation & Analysis
- Flow Cytometry
- Genomics & Epigenetics
- Microscopy & Imaging
- PCR, qPCR & qRT-PCR
- Bioscience Mastery
- Basic Lab Skills & Know-how
- Career Development & Networking
- Dealing with Fellow Scientists
- Equipment Mastery & Hacks
- Getting Funded
- Lab Safety
- Lab Statistics & Math
- Organization & Productivity
