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For many students, a PhD project is the first opportunity to really sink your teeth into your very own research project over a long period of time. This initial period is exciting but can also be a little daunting. Where do you begin? How do you actually design your first experiments? I mean, what are…
A few years ago, when I was working for a biotechnology company, I got a special letter in the mail. The NIH asked me to be an ad-hoc grant reviewer for small business grants. Although I drew these lessons from the NIH grant review process, they can probably be applied to many granting agencies. If…
Have you ever needed to work in a cold room for a long period of time? For example, if you need to dialyze or purify a protein of interest that is temperature sensitive, working in a 4°C cold room might be the only way to accomplish the work. Well, you are in luck. I dislike…
The scientific method naturally includes the so-called “trial and error” approach. And you can think of your PhD experience in the same way. My PhD experience is a long story, and I’ve made a lot of mistakes. Therefore, I’ll share some of my trials and errors in earning a PhD to help you avoid the…
Writing manuscripts is an integral part of research. And being listed as an author on a published article is the most cherished dream of a research scholar/ graduate student. However, what about the corresponding author role? During your Ph.D tenure, you will be encouraged to compile your data and write manuscripts based on your results….
If you’ve ever had backache from sitting at the microscope or biosafety cabinet, these tips may be useful for you!
If you type on a keyboard, pipette, or do anything repetitive with your hands for a long time, chances are you’ve felt it: numbness in the base of the thumb, pain in the wrist, or a weak feeling in your hand. These sensations can come from a lot of things, but the symptoms add up…
The precision and accuracy of even the best calibrated pipette can be wiped out if you choose the wrong kind of tips. Depending on the experiment you are doing, the wrong kind of tips can also make your pipette a source of contamination, lead to waste of precious samples or reagents—or even cause you physical…
Here’s a few things to take into consideration when starting up a new lab. Starting anything new is understandably overwhelming, but let’s break it down and go through the main points of designing your own laboratory. Purpose of Your New Lab The purpose and function of your proposed lab sets the course for the tasks…
It’s often said that great leaders have a knack for bringing out the best in those that follow. In turn, followers enjoy the work they do and will take the initiative to soar far above and beyond what is asked of them. A less effective scientific leader may unknowingly squander potential that might have flourished…
For many scientists the most intimidating aspect of undertaking a PhD isn’t the long hours in the lab or the uncertain nature of the job length in academia that follows it. It’s the thought of attempting to write up 4+ years of work into a single cohesive thesis! The thesis writing process can vary greatly…
We have all been to awful talks—hours of slides crammed with data, given by presenters who assume you know as much as they do. But hopefully you’ve also seen a great scientific talk. A talk in which you’re walked through a story, eagerly anticipating each question and data point, until you finally reach a conclusion…
Why do we need scientific collaboration? There is no science without collaboration: science is incredibly social. When you publish a paper or even a conference abstract, you collaborate with editors or a committee to produce an outcome (successful journal or scientific event) together. So, you have to understand the principles of collaboration even if you…
Hello, my name is Emilee and it’s been 5 months since I last yelled “That’s it, I quit graduate school!” It comes in waves, like the build-up of ripples at the beach followed by the crash against the shore’s rocks, or the slow and steady climb up a rail on a roller coaster followed by…
I’m an anxiety-ridden stress ball 90% of the time. Graduate school only amplifies my nervous energy, and it’s a struggle. However, recently, while I rushed to catch a bus, I had a life altering experience using a mental technique called “reframing” From “Flipping Out” to Flipping the Switch to “Cool” It rained heavily. I balanced…
Academia or industry? Basic research or applied research? You are thinking of what to do next. What is right for you? Honestly, it is a never ending discussion. So what should you do? Here are some insider tips from a person who has worked in both biotech industries and universities. The Freedom to Manage your Own…
An academic lab is a unique working environment. Lab members are expected to take responsibility for their own research projects and perform the work quickly and efficiently. However, unlike an industrial or corporate setting, there are often no clearly defined management structures. This means that when it comes to communal equipment, reagents and resources, individual…
A good scientist must see to believe… but if you just landed in the lab and things aren’t working, maybe it’s not you. We all love to try and save our hypothesis, but in this publish or perish climate, looking the other way during truth bending happens, and it happens a lot. Here are some…
Without good planning and preparation, writing your thesis can be a nightmare. Here are some tips on how to make the process a whole lot easier.
If there is one profession that benefited from globalization, it is the medical writer. While the university research groups shrink and global biomedical companies fire their research stuff, medical writing companies are expanding, providing stable jobs with good salaries. The American Medical Writers Association (AMWA) reported in 2011 that the median salary of an experienced…
Sometimes working with a liquid handling machine seems a bit like wrangling a wild mustang—I know what I want it to do, but the software doesn’t work that way. That’s particularly true when working with 96-well plates. So, sometimes you have to think “outside the box.” Don’t limit yourself to what the manufacturer intended (but…
Scientific research is a demanding and stressful career requiring lots of patience, dedication and hard work. Sadly the monetary benefits are not commensurate with the effort. Moreover, lack of opportunities, uncertainty, instability and the pressure to publish makes a traditional academic science career difficult. Inspiring (forcing?) many scientists and researchers to leave their traditional science…
One of the many perks that we often experience as graduate students is the chance to work with a collaborating lab on a research project. A successful collaboration results in: I recently came back from a visit to one of my collaborator’s lab, and wanted to share the aspects that I felt were most important…
Nowadays, it is no longer absolutely true that applying for a PhD means that you are striving for an academic position in the future. Although a majority of graduate students are certainly still aiming for a career in academia, and will thus benefit from doing a postdoc or two, more and more graduates are pursuing…
In the last years, the need for using statistical testing in bioscience has grown exponentially and so has the development of statistical software. It is now common that everyone is using some sort of stats in their basic research. Among the skillful biostatisticians, R is the most popular software for data analysis, but not all…
The gap year I intended to take between my Master’s degree and hypothetical Ph.D. is now going into its 4th year. Here’s why I’m not worried. These days it seems like undergraduates are proceeding en masse to graduate programs shortly after completing their senior year of college. An abundance of undergraduate research opportunities and poor…
BLAST is the most popular bioinformatics online tool. But in order to properly use it, you have to understand that is not just a search query against a database but something far more complicated, and the information you get back far more…precious!
A PhD, like any worthy endeavor in life, requires hard work, patience and perseverance. It also involves challenges that will make you doubt your choice to pursuit an advanced degree in the first place. It is inevitable that a series of failed experiments or that one paper rejection will bring you down and temporarily make…
When it comes to data analysis and interpretation, you need to be very clear about the meaning of a given p value and be aware of all its intrinsic limitations.
Ask a scientist why they love their job, and they will likely tell you it’s because they get to see and discover amazing things! Why, then, does science class in school never reflect this? A major problem identified in our society is lack of science interest and literacy. Mobile labs are helping to turn the…
Basic Local Alignment Search Tool (BLAST) remains the cornerstone of biological sequence analysis. When users have one or few queries, the data are easy to interpret based on the graphical output that the search provides. However, when you have to analyze hundreds or a few thousand queries, running graphical outputs can be computationally intensive, difficult…
Whether you’re just beginning, or nearing the end of your undergraduate career, getting involved in research can be overwhelming and stressful. There are many factors to consider, so keep it simple and focus on the most important ones: What area of research motivates you? What organisms do you find interesting? Are there any research professors…
Sometimes, you have to work with radioactive materials in the lab. If you happen to be one of those lucky individuals, it is important to take extra precautions in your work to ensure your safety, and good results! Here are my tips to make sure you radiate confidence doing your experiments. Know Your Element It…
Graduate students in the United States are privileged when it comes to picking their prospective labs: most programs have student rotate through several laboratories to help them choose their PhD lab. Here are some suggestions for questions to ask.
Pat yourself on the back, you saw a post with the word “coding” in the title and you didn’t freak out or glaze over. That’s the first step. Coding seems to have such a stigma attached to it; people tend to think that it’s incomprehensible nonsense that they could never learn, and that it has…
As a scientist myself, I have always been focused on performing experiments to achieve my sole goal of producing data for a publication. Recently I started paying attention to the waste I solely generate on a regular basis in the lab. Starting from disposable Eppendorf tubes and pipette tips, to labels and Petri plates, it…
Let’s face it, at least once in your lab life you are going to need a favor. You may need to go on vacation, you may be sick or you may just be a little overwhelmed at the bench. At least once, you will need to ask for a little help and someone will surely…
In the frenzy of today’s scientific publication landscape, it is essential to take a proactive stand at your online visibility and reputation. There are online tools that can help you make yourself spotted and translate your hard work and high-quality science into actual impact. So if you are interested in improving your chance of landing…
In Part 1 of this article, I introduced you to using code for basic image manipulation in ImageJ and working with the command recorder to expand your coding vocabulary. I covered how to make a simple macro, how to edit it and then save it to be run again another time. If you skipped the…
Working in a lab can be stressful, there is so much to do, and so little time to do it that we often feel overwhelmed. Sometimes you come into the lab and there are 15 experiments that just need to be done, so you throw on some music and start doing a bunch of them…
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