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Sigma-Aldrich® Advanced Genomics

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Articles by Sigma-Aldrich® Advanced Genomics

Image of a microplate use to show how CRISPR can be scaled to undertaking CRISPR screening.

Level Up Your Drug Screening With CRISPR

By Sigma-Aldrich® Advanced Genomics | June 24, 2020

Discover how CRISPR can be scaled up for drug screening applications.

Image of DNA transcriptio to show how CRISPR can modify gene expression using CRISPRa and CRISPRi

Why You Should Consider Adding CRISPRa and CRISPRi to Your Toolbox

By Sigma-Aldrich® Advanced Genomics | May 27, 2020

Find out how CRISPR-mediated gene activation (CRISPRa) and repression (CRISPRi) work and why you should consider using them in addition to your CRISPR knockouts.

Image of T cells and cancer cells highlighting how CRISPR can be used to enhance T cells anti cancer abilities.

A CRISPR Approach to Immuno-Oncology

By Sigma-Aldrich® Advanced Genomics | May 13, 2020

T cells can be tricky to engineer with CRISPR. Find out the key considerations when editing these cells and how you can overcome any associated challenges.

DNA being modified using a tool to represent modified CRISPR nuclease formats

How to Understand CRISPR Formats and Their Applications

By Sigma-Aldrich® Advanced Genomics | May 6, 2020

Find out how modified variants of CRISPR nucleases provide gene editing with reduced off-target effects and can even control gene expression without altering the DNA sequence.

Image of sequencing data to depict validating CRISPR

How to Validate a CRISPR Experiment  

By Sigma-Aldrich® Advanced Genomics | April 29, 2020

Discover how to validate your CRISPR gene editing, from the successful delivery of CRISPR reagents to the confirmation of desired genetic and phenotype changes.

Image of CRISPR-Cas complex targeting DNA with gRNA

CRISPR Gene Editing: Considerations and Getting Started

By Sigma-Aldrich® Advanced Genomics | April 22, 2020

Discover how to get started with CRISPR gene editing in your experiments with our key considerations.

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