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Sigma-Aldrich® Advanced Genomics

Unlocking research potential requires more than just cutting-edge technology. The Sigma-Aldrich® Advanced Genomics portfolio offers a comprehensive suite of tools that covers genome engineering from design through to analysis—at any scale.

Target a single gene or screen a whole genome of any species with our fully customizable products that come with expertise that extends from discovery to therapy. For your custom cell line engineering or lentiviral manufacturing needs, we partner with you to harness the power of CRISPR, RNAi and ZFN to unleash your full research potential.

Image of two hands altering DNA to depict CRISPR genome editing

A Brief History of CRISPR-Cas9 Genome-Editing Tools

CRISPR-Cas9 in the Spotlight CRISPR-Cas systems, such as CRISPR-Cas9, are adaptive immune response systems that protect prokaryotes from bacteriophages. They ...
Image of a microplate use to show how CRISPR can be scaled to undertaking drug screening.

Level Up Your Drug Screening With CRISPR

Signaling pathways are critical for proper cellular function, from controlling cell proliferation to triggering necessary cell death. Errors ...
Image of DNA transcriptio to show how CRISPR can modify gene expression

Why You Should Consider Adding CRISPRa and CRISPRi to Your Toolbox

CRISPR/Cas9 gene editing has become an increasingly popular solution for introducing permanent loss-of-function (LOF) mutations by generating double-strand ...
Image of T cells and cancer cells highlighting how CRISPR can be used to enhance T cells anti cancer abilities.

A CRISPR Approach to Immuno-Oncology

T cells are central players in the adaptive immune response and have a key role in the defence ...
DNA being modified using a tool to represent the various CRISPR tools available.

How to Understand CRISPR Formats and Their Applications

The primary components of the CRISPR gene editing system are a bacterially-derived nuclease (e.g. Cas9) and a guide ...
Image of sequencing data to depict validation of successful CRISPR gene editing.

How to Validate a CRISPR Experiment  

As with any research experiment, it's vital that you validate your CRISPR-driven gene editing. At a minimum, you ...
Image of CRISPR-Cas complex targeting DNA with gRNA

CRISPR Gene Editing: Considerations and Getting Started

The CRISPR (Clustered, Regularly Interspaced, Short Palindromic Repeats)–Cas system evolved in microbes as a defense mechanism to protect ...

Bioinformatics: It’s Not All About Genomics

Bioinformatics is perhaps best known as the conglomerate of advanced methods for analyzing genomics data, but it’s also ...

Getting Started with NGS Bioinformatics

If you’re a bench biologist who has decided to incorporate next-generation sequencing (NGS) bioinformatics into your research, you ...

CRISPR Nucleases: The Ultimate Guide To Selection

CRISPR nucleases continue to dominate the gene-editing landscape because they are powerful and easy-to-use gene-editing tools. Their rapid ...

CRISPR Multiplexing Strategies: What’s The Choice?

Although multiplex CRISPR gene editing can be accomplished by simply introducing more than one gRNA to your target ...

Multiplex CRISPR Gene Editing: What’s It For?

The RNA-guided nature of CRISPR nucleases (e.g., Cas9, Cpf1) makes them highly amenable to multiplex applications, including multi-gene ...
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