Leica Microsystems is a world leader in providing innovative microscopy, camera and software solutions for imaging and analysis of macro-, micro- and nanostructures.
Lab Meetings Live: CRISPR methods, techniques & advice
Lab Meetings Live: CRISPR methods, techniques & advice Open Access Virtual Conference Date: Wednesday, 21st September 2022Time: 2pm BST | 9am EST | 6am PST Lab Meetings Live is an ongoing series of intimate virtual conferences, with one important distinction: while the focus of most conference content is on sharing the latest research results, Lab…
Visualizing protein-protein interactions by non-fitting and easy FRET-FLIM approaches
Visualizing protein-protein interactions by non-fitting and easy FRET-FLIM approaches LIVE WEBINAR Date: Tuesday, July 19th 2022Time: 3pm London, 4pm Berlin, 6pm Dubai Understanding molecular interactions in living cells is one of the key elements to deciphering the molecular mechanisms underpinning most cellular functions. The gold standard for studying protein-protein interaction is Förster resonance energy transfer…
Advances in Cellular Imaging by Cryo-3D Correlative Light and Electron Tomography
Advances in Cellular Imaging by Cryo-3D Correlative Light and Electron Tomography LIVE WEBINAR Date: Friday, July 1st 2022Time: 10am London, 11am Berlin, 1pm Dubai Advances in cryo-electron tomography (cryo-ET), including cryo-focused ion beam (FIB) milling for the thinning of cells and new cryo-TEM instrumentation, allow the visualization of molecular sociology inside cells in near-native states.…
Discover a new era in microscopy
Meet Mica.Discover a new era in microscopyMeet Mica. Virtual ShowcaseAvailable On Demand In this fun and interactive 90-minute showcase event, scientists from Leica Microsystems invite you to experience how microscopy has changed with the arrival of the world’s first imaging Microhub, Mica. Imagine having everything you need for your microscopy workflows in one place, with a…
Coral Cryo: Access What Matters
Leica’s new workflow solution for CryoETCoral Cryo: Access What MattersLeica’s new workflow solution for CryoET Coral Cryo: Access What MattersLeica’s new workflow solution for CryoET VIRTUAL LAUNCH EVENT Date: Wednesday, April 27th 2022Time: 2pm London, 3pm Berlin, 5pm Dubai Leica Microsystems’ Coral Cryo is a workflow that helps you target your area of interest for cryo-electron tomography (CryoET). Including the…
See the Hidden: Cancer Research
See the Hidden: Cancer Research LIVE Online Workshop Imperial College London Edition Available On Demand Leica Microsystems is pleased to welcome you to the 4th virtual edition of our popular See the Hidden Workshop Series hosted by Microscopy Focus, which will explore the next generation of methodologies, techniques, and workflows that are helping to accelerate…
Mapping microscopic viscosity and temperature using molecular rotors
Mapping microscopic viscosity and temperature using molecular rotors LIVE WEBINAR Date: Tuesday November 30th 2021Time: LONDON 16:00 | BERLIN 17:00 | DUBAI 20:00 Viscosity is one of the main factors which influence diffusion in condensed media. In a cell, microscopic viscosity (microviscosity) can play a role in several diffusion-mediated processes, such as drug delivery, signaling,…
Ultramicrotomy for room temperature and cryo applications
Ultramicrotomy for room temperature and cryo applications ONLINE WORKSHOP Available On Demand Ultramicrotomy is a proven and universally accepted technique for sample preparation for TEM, SEM, AFM, etc. It permits the fine internal structures of samples to be visualized and analyzed at nanometer-scale resolution by producing ultrathin sample sections in a fast and clean manner.…
Translational Cancer Research
Translational Cancer Research See the Hidden – LIVE Online Workshop Available On Demand Understanding cancer biology has become increasingly dependent on imaging. High-resolution imaging is vital for studying genetic and cell signaling changes that underlie cancer, whereas live-cell imaging is crucial for a deeper understanding of disease mechanisms. Microscopy techniques are also essential for the…
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Hyperplex cancer tissue analysis at single cell level with Cell DIVE™
Hyperplex cancer tissue analysis at single cell level with Cell DIVE™ Available On Demand The H2P2 histopathology platform team have been mastering immunohistochemical staining and multiplexing for more than 15 years. With Cell DIVE technology, they offer the scientific community the opportunity to perform hyperplex labeling with up to 50 labels on a single tissue…
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High-resolution 3D imaging uncovers vascular control of tissue ageing
High-resolution 3D imaging uncovers vascular control of tissue ageing Wednesday 15th September 2021LONDON 16:00 BST | BERLIN 17:00 CET | DUBAI 19:00 GST Ageing is associated with alterations in tissue homeostasis and a decline in tissue functions. Blood vessels provide supportive microenvironments for various cell types to maintain tissue homeostasis and organ function. However, ageing…
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In the right place at the right time: How to successfully implement the Leica Nano workflow
In the right place at the right time: How to successfully implement the Leica Nano workflow Available On Demand Many electron microscope (EM) workflows start with sample fixation, followed by sample preparation and EM imaging. However, samples displaying interesting behavior tend to be rare, and finding the “right cell” can be time-consuming and tedious. The…
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See The Hidden: Artificial Intelligence in Microscopy
See The Hidden Artificial Intelligence in Microscopy Available On-Demand Introduction to AI for Microscopists: all you need to know Machine and deep learning technologies already play a major role in everyday life – think Alexa, Tesla’s Autopilot, Spotify, Amazon or YouTube. In the last 3 years, microscopists have started to use “AI based” solutions for…
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Intravital Microscopy of Cancer
Intravital Microscopy of Cancer Available on Demand In this webinar, you will learn: about intravital microscopy techniques that allow you to monitor stem cells and cancer cells in real-time in vivo; how these techniques can help you study the identity and migratory behavior of cancer stem cells; how intravital microscopy uses multiphoton confocal microscopy to…
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Visualising protein degradation and aggregation in the living cell
Visualising protein degradation and aggregation in the living cell Available On Demandat MicroscopyFocus.com Watch Now In this webinar, Prof. Eric Reits will discuss how several neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Huntington’s disease, are characterized by the formation of protein aggregates, and that components of the ubiquitin-proteasome system (UPS) co-localize in these aggregates. This has…
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Life beyond the pixels: deep learning methods for single cell analysis
Life beyond the pixels: Deep learning methods for single cell analysis Available On Demand In this webinar, you will discover: the computational steps in the analysis of single cell-based large-scale microscopy experiments; a novel microscopic image correction method designed to eliminate illumination and uneven background effects; new single-cell image segmentation methods; the Advanced Cell Classifier,…
See The Hidden: Virtual Neurosciences Workshop
See The Hidden: Virtual Neurosciences Workshop This live online event brings together a series of scientific talks and microscopy showcases, centering around four specific topics in microscopy – 3D real time imaging*, laser microdissection, confocal nanoscopy and high pressure freezing techniques in electron microscopy. Each section will kick off with a scientific talk from one…
Exploring The Structure and Life Cycle of Viruses
The Virologist’s Toolbox for Electron Microscopy Specimen Preparation Available On Demand Speakers Frédéric Leroux Advanced Workflow SpecialistLeica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to the physics department at the University of Antwerp…
From Organs to Tissues to Cells: Analyzing 3D Specimens with Widefield Microscopy
On Demand Speakers Dr. Falco Krüger Advanced Workflow Specialist Widefield Life Science Research DivisionLeica Microsystems Falco did his PhD in Biology at the Plant Cell Biology chair of Prof. Karin Schumacher at the Centre for Organismal Studies (COS) in Heidelberg, Germany. For his research on vacuole biogenesis in Arabidopsis thaliana, he used several different confocal…
Revealing functional mechanisms of synaptic transmission by high-pressure freezing
On Demand Speakers Frédéric Leroux Advanced workflow specialist, Leica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to the physics department at the University of Antwerp where he obtained his PhD in 2012. At…
Workflows and instrumentation for cryo-electron microscopy: an overview
Now On Demand Speaker Frédéric Leroux Advanced workflow specialist, Leica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to the physics department at the University of Antwerp where he obtained his PhD in 2012.…
THUNDER Imagers: High performance, versatility and ease-of-use for your everyday imaging workflows.
THUNDER Imagers: High performance, versatility and ease-of-use for your everyday imaging workflows. In this webinar, you will learn: How to get sharp, high quality images from thick 3-dimensional microscope samples How to shorten your imaging workflow from image acquisition to data analysis A broad spectrum of imaging workflows for a range of life science applications…
Basics of Fluorescence Lifetime Imaging and FLIM Applications to FRET Biosensors
Basics of Fluorescence Lifetime Imaging and FLIM Applications to FRET Biosensors In this tutorial you will learn: How researchers (Anzilotti 2019) used FLIM to elucidate the mechanisms responsible for a B cell deficiency A new approach to measure the cellular function of the Zn2+ transporter ZIP7 in primary mouse cells, comparing wild-type and CRISPR-Cas9 derived mutant cells…
Array Tomography for SEM 3D Reconstruction
Array Tomography for SEM 3D Reconstruction Speakers Frank Assen Robert Ranner Tutorial abstract Array tomography (AT) is a 3D image reconstruction technique for high resolution, quantitative analysis of biological structures. For optimal results, ultrathin and ordered sections are an absolute requirement. In this webinar you will get tips and tricks to optimize the workflow of…
Expanding the Limits of Electron Microscopy Sample Preparation with the Leica EM ICE High Pressure Freezer
Expanding the Limits of Electron Microscopy Sample Preparation with the Leica EM ICE High Pressure Freezer In this tutorial you will learn: Improved vitrification: Specimen vitrification without synchronisation fluid Vitrification strategies: Optimized freezing for different techniques Light and electrical stimulation: Dissect cellular processes with millisecond precision A look into the future: freezing of crystals Speakers…
Live Cell Isolation by Laser Microdissection
Live Cell Isolation by Laser Microdissection In this tutorial, you will learn: How to best prepare your specimen for live cell isolation by laser microdissection How to optimize your laser microdissection workflow How to avoid common pitfalls of this technique Speakers Dr. Oleg Podgorny Tutorial abstract Laser microdissection is a tool for the isolation of…
LAS X Navigator Tutorial: Navigating live cell imaging
LAS X Navigator Tutorial: Navigating live cell imaging Speakers Dr. Avi Jacob Tutorial abstract Join Dr. Avi Jacob as he introduces you to the Leica LAS X Navigator, a software module that makes multiparametric acquisition and data review of large data sets easier than you ever thought possible! In this tutorial, Dr. Jacobs will discuss:…
Super-resolved STED spectroscopy: New insights into molecular membrane dynamics
Super-resolved STED spectroscopy: New insights into molecular membrane dynamics Speakers Christian Eggeling Tutorial abstract Molecular interactions are key in cellular signalling. They are often ruled or rendered by the mobility of the involved molecules. We present different tools that are able to determine such mobility and potentially extract interaction dynamics. Specifically, the direct and non-invasive…
Precise and lightning-fast spectral Fluorescence Lifetime Imaging at video rate integrated in a high-end confocal microscope
Precise and lightning-fast spectral Fluorescence Lifetime Imaging at video rate integrated in a high-end confocal microscope Speakers Kees Jalink Professor, The Netherlands Cancer Institute Tutorial abstract Förster (Fluorescence) Resonance Energy Transfer (FRET) has become a powerful tool to study protein-protein interactions and signal transduction in living cells. FRET is commonly read out either by detecting…
How to Conduct Localized Proteomics of Microscopic Regions
Precise and lightning-fast spectral Fluorescence Lifetime Imaging at video rate integrated in a high-end confocal microscope In this tutorial, you will learn: How to perform isolated proteomics of microscopic regions of interest How to use this technique with FFPE tissue How proteomics can help you understand molecular mechanisms in disease Speakers Dr. Eleanor Drummond Tutorial abstract…
Enhance Your Imaging with Super-Resolution: Improve Spatial Resolution and Increase Signal to Noise Ratio in Difficult Samples
In these informative case studies, you will learn how: HyVolution 2 can improve the spatial resolution you get from your sample, whilst remaining gentle to the fluorophores HyVolution 2 overcomes issues experienced with other imaging modalities, even in difficult samples such as plant material, increasing resolution and signal to noise ratio, thereby facilitating downstream image…
Revealing Cellular Dynamics with Millisecond Precision – The New Tool That Turned Electron Micrographs into Motion Pictures of Neural Communication
Revealing Cellular Dynamics with Millisecond Precision – The New Tool That Turned Electron Micrographs into Motion Pictures of Neural Communication In this tutorial: What if you can dissect the cellular dynamics with millisecond precision? What if you can unravel the morphological transformation of a neuron millisecond by millisecond using electron microscopy? Could this be even…
Using FIT probes and Super-Resolution Microscopy to Decipher Steps of mRNP Assembly in Developing Oocytes
In this webinar, presented by Dr. Imre Gaspar of the Developmental Biology Unit at EMBL, Heidelberg, you will learn: Importance of mRNA localization and function of mRNPs. Advantages of using fluorogenic FIT probes to visualize mRNPs in vivo and in fixed specimen. How super-resolution microscopy can identify factors required for mRNP biogenesis. Abstract: All mRNA…
Leica Microsystems Laser Microdissection – Dissection Perfection
Leica Microsystems Laser Microdissection – Dissection Perfection Speakers Dr. Raffaella Maria Balestrini Dr. Falk Schlaudraff Tutorial abstract Leica Microsystems Laser Microdissection systems are the method of choice for laser-based microscopic sample dissection and collection. Laser Microdissection (LMD) is a microscopic technique for isolating homogeneous, specific and pure targets from heterogeneous samples for downstream analysis (DNA,…
The Best of Both Worlds: Combining Light Sheet and Confocal Microscopy
Abstract: Living cells and organisms often suffer from the high light intensities that are used in conventional imaging. Light sheet microscopy reduces phototoxic effects and bleaching, by only illuminating a specimen in a single plane at a time whilst the signal is detected in a perpendicular direction. In combination with high-speed cameras for image acquisition,…
Create Publication Quality Fluorescence Microscopy Images with the Help of Leica Microsystems’ Science Lab Resource
Have you ever been shown how to use a microscope properly? Or do you just dive right onto the microscope with little or no training and scant knowledge of the basics, then twiddle knobs, snap photos and expect the publication-quality images to appear? If it’s the latter you are certainly not alone! If only there…
Microscope maintenance: changing and aligning your mercury burner
Mercury burners are one of the most common light sources used in fluorescence microscopes, producing a wide spectrum of wavelengths making them a great light source for viewing your samples. But they do have their issues – one of which is their propensity to break or become damaged if not used and cared for correctly, which…
Fundamentals of Fluorescence Microscopy
What you will learn from this webinar: How a fluorescence microscope works What resolution you can expect to achieve from different microscopes How to choose the right fluorophore Four key elements that require optimization for fluoresence microscopy Summary: Fluorescence microscopy has become one of the most important tools in the biologist’s toolbox. In this presentation…
How to Pick the Right Microscopy Technique
In this webinar you will learn: about the variety of imaging techniques that are available how to pick the right technique to answer your scientific question. Summary: There is a plethora of microscopy techniques available and it can be daunting to figure out which technique is the right one for you. This webinar is designed…
Basics of Confocal Microscopy
In this webinar you will learn: the basics of confocal laser scanning microscopy why and when you should use confocal microscopy how to get started with confocal microscopy including a demonstration of the key features on a Leica Microsystems confocal microscope Summary: Are you a confocal novice but interested in using this technique for your own research…
Fluorescence 101: A Beginners Guide to Excitation/Emission, Stokes Shift, Jablonski and More!
You may already use fluorescence as a tool in your microscopy and imaging work, but, do you know exactly what it is? Why are certain proteins and probes fluorescent? What causes this light emitting property? We’ll have a look at these and more questions in this article. Start with a definition We’ll start with a…
