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Hydrogen bonds are critical non-covalent bonds essential for the structural integrity and function of almost all biological molecules, particularly DNA and proteins. This article explains the fundamental chemistry of hydrogen bonds and nomenclature and highlights why they are critical for life.
If you’ve ever worked with proteins in the lab, you probably know just how critical protein purity and quality are for downstream applications. In this article, we’ll review the multitude of problems that are encountered with ‘bad’ protein samples and how you can analyze the purity and integrity of your favorite protein prior to using…
Predicting how proteins will fold in vivo is a Holy Grail of proteomics and theoretical chemistry. Current hopes are that this can be achieved by designing an in silico platform that can predict protein folding, either de novo (a.k.a. from scratch) or using known proteins as a guide. What would we need to do, why…
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