Experimental Tool-kit for Measuring Protein Stability

An Experimental Tool-kit for Measuring Protein Stability

Proteins in the cell are in a constant flux governed by events including synthesis and degradation. In an effort to make cells more efficient by reducing the unnecessary protein load, most proteins in the cell have a specifically defined half-life. Another reason why cells have evolved to degrade proteins is to ensure timely removal of…

Extracting Better Ubiquitin Data from Your Samples: Beyond the Cellular Skip

Extracting Better Ubiquitin Data from Your Samples: Beyond the Cellular Skip

The ubiquitin-proteasome system was discovered at the start of the 1980s, and people have been studying it ever since. Initially, researchers thought that tagging a protein with ubiquitin was the cell’s signal for the protein to be scrapped via the proteasome. But more research has shown that, as with all biology, once you’re up close and…