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Multiplex Annotated Tissue Imaging System (MANTIS®)

Multiplex Annotated Tissue Imaging System (MANTIS®)Genoskin’s integrated digital process for 3-D deconstruction of human skin immune landscapeLIVE WEBINAR Date: Wednesday, December 7th 2022Time: 3pm London, 4pm Berlin, 7pm Dubai Discover how to perform 10-color imaging of tissue samples using a confocal microscope, and see how this can allow assessment of the skin immune landscape. In…

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See the Hidden: Correlative Techniques for Electron Microscopy

See the Hidden:Correlative Techniques for Electron MicroscopyLIVE WORKSHOP Date: Tuesday, December 6th 2022Time: 1-4pm London, 2-5pm Berlin, 5-8pm Dubai In this next highly anticipated virtual edition of our See the Hidden Workshop Series, we dive into the ultrastructure of biological systems. We look at state-of-the-art Correlative Light and Electron Microscopy (CLEM) methods to guide specimen preparation and…

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Advanced Cryo Preparation Techniques

Advanced Cryo Preparation TechniquesLIVE WEBINAR Date: Tuesday, October 11th 2022Time: 10am London, 11am Berlin, 1pm Dubai In this webinar, you will discover: A step-by-step guide to optimizing your cryo-EM workflow Preparation tools for cellular and biological sample preparation Expert help and advice on capturing the perfect cryo-EM image Cryo-electron microscopy is becoming an important tool…

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Five-color STED with a single depletion laser and fluorescence lifetime phasor separation

Five-color STED with a single depletion laser and fluorescence lifetime phasor separationLIVE WEBINAR Date: Thursday, October 13th 2022Time: 3pm London, 4pm Berlin, 6pm Dubai Using a single depletion laser avoids laser misalignment and bleaching issues during stimulated emission depletion (STED) microscopy but limits the available fluorophores for use. Imaging with five fluorochromes using one depletion…

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The role of iron metabolism in cancer progression

The role of iron metabolism in cancer progressionLIVE WEBINAR Date: Tuesday, Sept 27th 2022Time: 3pm London, 4pm Berlin, 6pm Dubai Iron metabolism plays a role in cancer development and progression, and modulates the immune response. Understanding how iron influences cancer and the immune system can aid the development of new therapeutic approaches. In this webinar,…

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Ultramicrotomy Masterclass: The Cutting Edge of Sectioning

Ultramicrotomy: The Cutting Edge of SectioningLIVE WEBINAR Date: Thursday, September 29th 2022Time: 2pm London, 3pm Berlin, 5pm Dubai Discover ways to refine your ultramicrotomy technique to improve electron microscopy (EM) imaging for a wide range of samples and EM techniques. In this webinar, you will learn: Ways experts refine their ultramicrotomy workflows for specific applications…

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See the Hidden: Spatial Biology II

See the Hidden: Spatial Biology IILIVE WORKSHOP Date: Tuesday, September 13th 2022Time: 1:30-4:30pm London, 2:30-5:30pm Berlin, 4:30-7:30pm Dubai In this next virtual edition of our See the Hidden Workshop series, we will continue to explore the topic of Spatial Biology, which we started to examine earlier this year. In Spatial Biology Part II, join us…

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Live-cell fluorescence lifetime multiplexing using organic fluorophores

Live-cell fluorescence lifetime multiplexing using organic fluorophoresLIVE WEBINAR Date: Wednesday, September 7th 2022Time: 3pm London, 4pm Berlin, 6pm Dubai Spectrally resolved detection of fluorophores with distinct excitation and emission spectra is a routine method for performing multiplexed fluorescence microscopy. However, as many commonly used fluorophores have spectral overlap, this technique is limited to three to…

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See the Hidden: Spatial Biology

See the Hidden: Spatial BiologyLIVE WORKSHOP Date: Thursday, July 7th 2022Time: 1-4pm London, 2-5pm Berlin, 4-7pm Dubai In this next highly anticipated virtual edition of our See the Hidden Workshop Series, we will start to examine emerging microscopy techniques being used to study cells within a spatial 2D and 3D context. We will examine the…

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Understanding the Basis for Morphogenesis in the Early Mammalian Embryo

Understanding the Basis for Morphogenesis in the Early Mammalian EmbryoLIVE WEBINAR Date: Wednesday, July 13th 2022Time: 3pm London, 4pm Berlin, 6pm Dubai During embryonic development, the patterning of tissues is closely coordinated with their morphogenesis. Starting from a predominantly symmetric zygote, the embryo progressively acquires axial asymmetries that form the basis for the gradual establishment…

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Visualizing protein-protein interactions by non-fitting and easy FRET-FLIM approaches

Visualizing protein-protein interactions by non-fitting and easy FRET-FLIM approachesLIVE WEBINAR Date: Tuesday, July 19th 2022Time: 3pm London, 4pm Berlin, 6pm Dubai Understanding molecular interactions in living cells is one of the key elements to deciphering the molecular mechanisms underpinning most cellular functions. The gold standard for studying protein-protein interaction is Förster resonance energy transfer (FRET).…

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Advances in Cellular Imaging by Cryo-3D Correlative Light and Electron Tomography

Advances in Cellular Imaging by Cryo-3D Correlative Light and Electron TomographyLIVE WEBINAR Date: Friday, July 1st 2022Time: 10am London, 11am Berlin, 1pm Dubai Advances in cryo-electron tomography (cryo-ET), including cryo-focused ion beam (FIB) milling for the thinning of cells and new cryo-TEM instrumentation, allow the visualization of molecular sociology inside cells in near-native states. However,…

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Discover a new era in microscopy
Meet Mica.

Discover a new era in microscopyMeet Mica. Virtual ShowcaseAvailable On Demand In this fun and interactive 90-minute showcase event, scientists from Leica Microsystems invite you to experience how microscopy has changed with the arrival of the world’s first imaging Microhub, Mica. Imagine having everything you need for your microscopy workflows in one place, with a…

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Coral Cryo: Access What Matters
Leica’s new workflow solution for CryoET

Coral Cryo: Access What MattersLeica’s new workflow solution for CryoETVIRTUAL LAUNCH EVENT Date: Wednesday, April 27th 2022Time: 2pm London, 3pm Berlin, 5pm Dubai Leica Microsystems’ Coral Cryo is a workflow that helps you target your area of interest for cryo-electron tomography (CryoET). Including the STELLARIS Cryo confocal system, the workflow gives you the precision to…

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See the Hidden: Cancer Research

See the Hidden: Cancer ResearchLIVE Online Workshop Imperial College London Edition Available On Demand Leica Microsystems is pleased to welcome you to the 4th virtual edition of our popular See the Hidden Workshop Series hosted by Microscopy Focus, which will explore the next generation of methodologies, techniques, and workflows that are helping to accelerate cancer…

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Mapping microscopic viscosity and temperature using molecular rotors

Mapping microscopic viscosity and temperature using molecular rotorsLIVE WEBINAR Date: Tuesday November 30th 2021Time: LONDON 16:00 | BERLIN 17:00 | DUBAI 20:00 Viscosity is one of the main factors which influence diffusion in condensed media. In a cell, microscopic viscosity (microviscosity) can play a role in several diffusion-mediated processes, such as drug delivery, signaling, and…

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Ultramicrotomy for room temperature and cryo applications

Ultramicrotomy for room temperature and cryo applicationsONLINE WORKSHOP Available On Demand Ultramicrotomy is a proven and universally accepted technique for sample preparation for TEM, SEM, AFM, etc. It permits the fine internal structures of samples to be visualized and analyzed at nanometer-scale resolution by producing ultrathin sample sections in a fast and clean manner. A…

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Translational Cancer Research

Translational Cancer ResearchSee the Hidden – LIVE Online Workshop Available On Demand Understanding cancer biology has become increasingly dependent on imaging. High-resolution imaging is vital for studying genetic and cell signaling changes that underlie cancer, whereas live-cell imaging is crucial for a deeper understanding of disease mechanisms. Microscopy techniques are also essential for the study…

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Hyperplex cancer tissue analysis at single cell level with Cell DIVE™

Hyperplex cancer tissue analysis at single cell level with Cell DIVE™ Available On Demand The H2P2 histopathology platform team have been mastering immunohistochemical staining and multiplexing for more than 15 years. With Cell DIVE technology, they offer the scientific community the opportunity to perform hyperplex labeling with up to 50 labels on a single tissue…

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High-resolution 3D imaging uncovers vascular control of tissue ageing

High-resolution 3D imaging uncovers vascular control of tissue ageing Wednesday 15th September 2021LONDON 16:00 BST | BERLIN 17:00 CET | DUBAI 19:00 GST Ageing is associated with alterations in tissue homeostasis and a decline in tissue functions. Blood vessels provide supportive microenvironments for various cell types to maintain tissue homeostasis and organ function. However, ageing…

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In the right place at the right time: How to successfully implement the Leica Nano workflow

In the right place at the right time:How to successfully implement the Leica Nano workflow Available On Demand Many electron microscope (EM) workflows start with sample fixation, followed by sample preparation and EM imaging. However, samples displaying interesting behavior tend to be rare, and finding the “right cell” can be time-consuming and tedious. The live-cell…

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See The Hidden: Artificial Intelligence in Microscopy

See The HiddenArtificial Intelligence in Microscopy Available On-Demand Introduction to AI for Microscopists: all you need to know Machine and deep learning technologies already play a major role in everyday life – think Alexa, Tesla’s Autopilot, Spotify, Amazon or YouTube. In the last 3 years, microscopists have started to use “AI based” solutions for image…

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Intravital Microscopy of Cancer

Intravital Microscopy of Cancer Available on Demand In this webinar, you will learn: about intravital microscopy techniques that allow you to monitor stem cells and cancer cells in real-time in vivo; how these techniques can help you study the identity and migratory behavior of cancer stem cells; how intravital microscopy uses multiphoton confocal microscopy to…

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Visualising protein degradation and aggregation in the living cell

Visualising protein degradation and aggregation in the living cell Available On Demandat MicroscopyFocus.com Watch Now In this webinar, Prof. Eric Reits will discuss how several neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Huntington’s disease, are characterized by the formation of protein aggregates, and that components of the ubiquitin-proteasome system (UPS) co-localize in these aggregates. This has…

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Life beyond the pixels: deep learning methods for single cell analysis

Life beyond the pixels:Deep learning methods for single cell analysis Available On Demand In this webinar, you will discover: the computational steps in the analysis of single cell-based large-scale microscopy experiments; a novel microscopic image correction method designed to eliminate illumination and uneven background effects; new single-cell image segmentation methods; the Advanced Cell Classifier, a…

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See The Hidden: Virtual Neurosciences Workshop

See The Hidden: Virtual Neurosciences Workshop This live online event brings together a series of scientific talks and microscopy showcases, centering around four specific topics in microscopy – 3D real time imaging*, laser microdissection, confocal nanoscopy and high pressure freezing techniques in electron microscopy. Each section will kick off with a scientific talk from one…

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Exploring The Structure and Life Cycle of Viruses

Exploring The Structure and Life Cycle of Viruses The Virologist’s Toolbox for Electron Microscopy Specimen Preparation Available On Demand Speakers Frédéric Leroux Advanced Workflow SpecialistLeica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to…

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From Organs to Tissues to Cells: Analyzing 3D Specimens with Widefield Microscopy

From Organs to Tissues to Cells: Analyzing 3D Specimens with Widefield Microscopy On Demand Speakers Dr. Falco Krüger Advanced Workflow Specialist Widefield Life Science Research DivisionLeica Microsystems Falco did his PhD in Biology at the Plant Cell Biology chair of Prof. Karin Schumacher at the Centre for Organismal Studies (COS) in Heidelberg, Germany. For his…

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Revealing functional mechanisms of synaptic transmission by high-pressure freezing

Revealing functional mechanisms of synaptic transmission by high-pressure freezing On Demand Speakers Frédéric Leroux Advanced workflow specialist, Leica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to the physics department at the University of…

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Workflows and instrumentation for cryo-electron microscopy: an overview

Workflows and instrumentation for cryo-electron microscopy: an overview Now On Demand Speaker Frédéric Leroux Advanced workflow specialist, Leica Microsystems Frédéric Leroux completed his Master degree in Biology in 2007 at the University of Ghent where he gained experience in biological EM sample preparation. In 2008, he moved to the physics department at the University of…

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THUNDER Imagers: High performance, versatility and ease-of-use for your everyday imaging workflows.

THUNDER Imagers: High performance, versatility and ease-of-use for your everyday imaging workflows. In this webinar, you will learn: How to get sharp, high quality images from thick 3-dimensional microscope samples How to shorten your imaging workflow from image acquisition to data analysis A broad spectrum of imaging workflows for a range of life science applications…

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Basics of Fluorescence Lifetime Imaging and FLIM Applications to FRET Biosensors

Basics of Fluorescence Lifetime Imaging and FLIM Applications to FRET Biosensors In this tutorial you will learn: How researchers (Anzilotti 2019) used FLIM to elucidate the mechanisms responsible for a B cell deficiency A new approach to measure the cellular function of the Zn2+ transporter ZIP7 in primary mouse cells, comparing wild-type and CRISPR-Cas9 derived mutant cells…

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Array Tomography for SEM 3D Reconstruction

Array Tomography for SEM 3D Reconstruction Speakers Frank Assen Robert Ranner Tutorial abstract Array tomography (AT) is a 3D image reconstruction technique for high resolution, quantitative analysis of biological structures. For optimal results, ultrathin and ordered sections are an absolute requirement. In this webinar you will get tips and tricks to optimize the workflow of…

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Expanding the Limits of Electron Microscopy Sample Preparation with the Leica EM ICE High Pressure Freezer

Expanding the Limits of Electron Microscopy Sample Preparation with the Leica EM ICE High Pressure Freezer In this tutorial you will learn: Improved vitrification: Specimen vitrification without synchronisation fluid Vitrification strategies: Optimized freezing for different techniques Light and electrical stimulation: Dissect cellular processes with millisecond precision A look into the future: freezing of crystals Speakers…

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Live Cell Isolation by Laser Microdissection

Live Cell Isolation by Laser Microdissection In this tutorial, you will learn: How to best prepare your specimen for live cell isolation by laser microdissection How to optimize your laser microdissection workflow How to avoid common pitfalls of this technique Speakers Dr. Oleg Podgorny Tutorial abstract Laser microdissection is a tool for the isolation of…

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LAS X Navigator Tutorial: Navigating live cell imaging

LAS X Navigator Tutorial: Navigating live cell imaging Speakers Dr. Avi Jacob Tutorial abstract Join Dr. Avi Jacob as he introduces you to the Leica LAS X Navigator, a software module that makes multiparametric acquisition and data review of large data sets easier than you ever thought possible! In this tutorial, Dr. Jacobs will discuss:…

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Super-resolved STED spectroscopy: New insights into molecular membrane dynamics

Super-resolved STED spectroscopy: New insights into molecular membrane dynamics Speakers Christian Eggeling Tutorial abstract Molecular interactions are key in cellular signalling. They are often ruled or rendered by the mobility of the involved molecules. We present different tools that are able to determine such mobility and potentially extract interaction dynamics. Specifically, the direct and non-invasive…

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Precise and lightning-fast spectral Fluorescence Lifetime Imaging at video rate integrated in a high-end confocal microscope

Precise and lightning-fast spectral Fluorescence Lifetime Imaging at video rate integrated in a high-end confocal microscope Speakers Kees JalinkProfessor, The Netherlands Cancer Institute Tutorial abstract Förster (Fluorescence) Resonance Energy Transfer (FRET) has become a powerful tool to study protein-protein interactions and signal transduction in living cells. FRET is commonly read out either by detecting the…

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How to Conduct Localized Proteomics of Microscopic Regions

Precise and lightning-fast spectral Fluorescence Lifetime Imaging at video rate integrated in a high-end confocal microscope In this tutorial, you will learn: How to perform isolated proteomics of microscopic regions of interest How to use this technique with FFPE tissue How proteomics can help you understand molecular mechanisms in disease Speakers Dr. Eleanor Drummond Tutorial abstract…

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Enhance Your Imaging with Super-Resolution: Improve Spatial Resolution and Increase Signal to Noise Ratio in Difficult Samples

In these informative case studies, you will learn how: HyVolution 2 can improve the spatial resolution you get from your sample, whilst remaining gentle to the fluorophores HyVolution 2 overcomes issues experienced with other imaging modalities, even in difficult samples such as plant material, increasing resolution and signal to noise ratio, thereby facilitating downstream image…

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