The End of the Beginning for Retrosynthetic Planning
On-demand
Lindsey Rickershauser, Ph.D.
Lindsey Hess Rickershauser, PhD, currently manages the sales and marketing for SYNTHIA™ in the Cheminformatics Technologies division of MilliporeSigma, a business of Merck KGaA, Darmstadt, Germany. In 2010 she received her PhD in organic chemistry from Johns Hopkins University, where she worked under Professor Gary Posner. Her PhD focused on synthesizing analogs of vitamin D for antiproliferative activity, semi-synthetic Artemisinin trioxane dimers for antimalarial activity and creating a methodology of enantioselective alpha- selenenylations and [2,3]-sigmatropic rearrangements leading to the preparation of alpha- hydroxy-(E)-beta, gamma-unsaturated esters.
After her PhD, Lindsey had a short venture in cheminformatics at the Chemical Abstracts Services where she worked on cataloging data into database format to make literature content searchable. She then felt the pull of the lab again and joined Cerilliant Corporation (then a subsidiary of Sigma-Aldrich) as a Senior Scientist specializing in certified reference materials in the clinical, diagnostic and forensic industries. During her 6-year tenure as a senior scientist, she specialized in stable label isotope incorporation to both pharmaceutical and illicit drugs and their metabolites (concentrating on D and 13C incorporation).
During this time she became more interested in cheminformatics and joined the Cheminformatics Technologies division after participating in an evaluation of a well-established retrosynthetic design software, which was acquired by MilliporeSigma in 2017. She has since become an in-house expert on the software and manages the sales and marketing for this product.
Close
In a continuously evolving landscape of in silico chemical intelligence and machine learning, computer-assisted synthetic planning has come to the forefront in the cheminformatics field. Here, we describe the evolution and use of SYNTHIA™, a retrosynthetic design software that has continually innovated to become a strategic and cutting-edge laboratory companion at the bench of every organic chemist.
In this webinar, you will learn about:
- how SYNTHIA™ was developed
- the innovations that have improved the technology
- the benchtop validations that have made the tool more useful.
SYNTHIA™ takes a unique approach to building an expert database of known reaction rules. It hand codes each transformation, enabling the tool to become a bench chemist’s ally by ‘learning’ chemistry much like a chemist would themselves, and suggesting diverse pathways towards their targets, thus generating ideas and providing cost-effective routes based on each user’s unique needs. As a product of over 15 years of research, this tool is poised not only to improve over time, but also to revolutionize the way chemists design pathways to their complex targets.
The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada.
All emails contain an unsubscribe link.You can review our privacy policy, cookie policy and terms and conditions online.
