The Mysterious World of Macrophages: How to Harness Them for Your Research
In this tutorial, you will learn:
- How to work with mouse and human macrophages
- The best methods for culturing macrophages
- The difference between M1 and M2 macrophages, and how to differentiate each population from monocytes
- What data to expect based on the conditions of your experiment
Although macrophages were first described by Elie Metchnikoff in 1882, plenty of mysteries are still associated with the cell type. Indeed, while macrophages were once considered simply “garbage trucks” of the immune system due to their phagocytic property, their substantial and multifaceted contribution to immunological responses and homeostasis is becoming more apparent. Macrophages can produce a wide range of cytokines and chemokines to influence the immune response toward healing or inflammation. In as such, they possess a great deal of plasticity to respond with either pro- or anti-inflammatory signals depending on the environmental milieu. Moreover, researchers are beginning to turn to macrophages to assist chimeric antigen receptor (CAR) T cells in various immunotherapies.
This webinar is presented by Anne Lodge, Chief Scientific Officer of Astarte Biologics. Connect with Anne on LinkedIn.