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How to Weigh Molecules with Light Using Mass Photometry

In this tutorial, you will learn:

  •    How mass photometry offers a universal way to study biomolecules
  •    The strengths and limitations of mass photometry
  •    How to use mass photometry to:
    1. accurately determine the degree of heterogeneity of a sample
    2. quantify the strength and kinetics of molecular interactions
    3. optimize conditions for sample stability and molecular interactions
    4. quantifying self-assembly
    5. precise characterization of molecular concentration

Mass photometry is a natural evolution of interferometric scattering microscopy that offers a universal way to study biomolecules that will change how research is performed across many fields of biomedical science.


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Prof Philipp Kukura

Tutorial abstract

Physiological and pathological processes are mediated by the interactions between different biomolecules. Studying these functional and malfunctional associations is key to elucidating the molecular mechanisms of life, and to develop new means to combating disease.

Successful in vitro studies of protein and macromolecular function rely heavily on well-defined samples. The purity, homogeneity, structural integrity, and activity of all components of these samples must be quantified.

While there are numerous established methods for sample quality assessment, mass photometry can accurately measure the mass of individual molecules in solution without the need for any labels. Mass photometry is a completely new technology that enables researchers to characterize biomolecular composition, structure, and dynamics.

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