Instituto de Investigación Sanitaria Gregorio Marañón
In this webinar, you will discover:
- what is currently known about the potential long-term dysregulation of the immune system that may be induced by SARS-CoV-2 infection, and its implications;
- how flow cytometry immune profiling can be used to track alterations in the immune system over time;
- the results of deep analysis of the immune system of COVID-19 recovered individuals, including new data on several immune system alterations;
- how these findings may lead to the identification of important prognosis markers for SARS-CoV-2 re-infection or the presence of long-term symptoms in some individuals.
SARS-CoV-2 has infected more than 200 million people worldwide, with more than 4 million associated deaths. Although more than 80% of infected people develop asymptomatic or mild COVID-19, SARS-CoV-2 can induce a profound dysregulation of the immune system. It is therefore important to investigate if clinically recovered individuals exhibit long-term dysregulation of the immune system which could constitute a risk factor for re-infection and the development of other pathologies.
Join this webinar to see the results of a deep analysis of the immune system in 35 COVID-19 recovered individuals previously infected with SARS-CoV-2 compared to 16 healthy donors, by flow cytometry immune profiling. Samples from COVID-19 individuals were analyzed from 12 days to 305 days post-infection. Alterations in the values of some T-cell, B-cell, and innate cell subsets were observed 10 months post-infection in recovered COVID-19 patients compared to healthy controls. Moreover, increased levels of circulating follicular helper type 1 (cTfh1), plasmablast/plasma cells, and follicular dendritic cells (foDC) was found in recovered COVID-19 individuals, indicating that the Tfh-B-foDC axis might be functional to produce specific immunoglobulins 10 months post-infection.
These data indicate that the presence of this axis and the accompanying immune system alterations could constitute prognosis markers and could play an important role in potential re-infection or the presence of long-term symptoms in some individuals.