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Live Webinar Date: 28 March, 2019

Cryo-Electron Microscopy and the Complexity of Cancer

Start Time:

Berlin Time: 3:30 pm
Boston Time: 10:30 am
San Diego Time: 7:30 am

Webinar Summary

Shed light on disease with an electron beam, one molecule at a time

In this webinar, you will learn:

  • How structural biology can change the face of your research
  • The biological challenges of cancer research
  • Advantages of cryo-EM for your research

Covering both biology and methodology, this webinar will explain how single-particle cryo-electron microscopy enables us to gain insight into cancer development through the detailed analysis of molecular structure.

In single-particle cryo-EM, hundreds of thousands of images formed by electron scattering of individual molecules or complexes are analyzed to derive their three-dimensional structure. Technological and computational advances have dramatically transformed the field of cryo-EM in the past years, enabling structural insights at near-atomic resolution into assemblies that had not been tractable using any other structural biology technique. Consequently, cryo-EM has become a mainstream method structural biology, with a multitude of new facilities and research groups being established all over the world within just a couple of years.  

This webinar will address the roles that structural biology has been playing in cancer research, uncovering cellular processes involved in cancer development and protection, and guiding drug discovery efforts. The biological challenges of cancer research will be discussed, as well as the unique strengths of cryo-EM as an experimental approach towards these questions, briefly covering the methodology and procedures in sample preparation and data processing. We will illustrate these aspects with some of the latest research from the laboratory of Eva Nogales at UC Berkeley and assess the promises and challenges of cryo-EM in our fight against cancer.

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Presented By

Simon Poepsel

Ph.D., University of California at Berkeley
Speaker Profile

Simon obtained is B.Sc. in Medical Biology from the University of Duisburg-Essen, Germany in 2008. As a graduate student in the laboratory of Michael Ehrmann, he studied the biochemistry of protein quality control, specifically the disintegration and proteolysis of pathological tau aggregates by the serine protease HTRA1. For his postdoctoral research, Simon joined the group of Eva Nogales at the University of California at Berkeley in 2015. Using cryo-electron microscopy, he has been characterizing the structure of the human epigenetic regulator Polycomb Repressive Complex 2 (PRC2) and its regulatory interactions with various chromatin substrates. In summer 2019, Simon will be moving back to Germany to establish an independent research group at the Center for Molecular Medicine Cologne (CMMC).

Live Webinar Date: 28 March, 2019

Cryo-Electron Microscopy and the Complexity of Cancer

Start Time:

London Time: 3:30 pm
Boston Time: 10:30 am
San Diego Time: 07:30 am