Antibodies and Antibody-Drug Conjugate Higher Order Structures Revealed

[RedShiftBio] Webinar Dec 12 2018 Antibodies and Antibody-Drug

A Guide to Harnessing DNA Assembly for Drug Discovery
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Tutorial Presented By

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RedShiftBio is the developer of Microfluidic Modulation Spectroscopy (MMS). MMS addresses the limitations of current technologies and provides direct, label-free protein analysis. It uses a tunable mid-infrared quantum cascade laser to generate an optical beam 1000 times brighter than those used in conventional FTIR, enabling the measurement of more concentrated samples, and the use of simpler detectors with no requirement for nitrogen cooling. The unique optical configuration of MMS delivers high sensitivity measurements over a wide concentration range of 0.1 – 200 mg/mL to 0.01 mg/mL, giving MMS a wider dynamic range than alternative protein characterization techniques.

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Karan K. Shah

Ioannis Papayannopoulos

Eugene Ma

Tutorial Video Abstract

In this webinar, you will find:

  • Characterization of mAb’s and ADC’s without the need for dilutions or concern for your formulation buffer’s excipient interferences, enabled by MMS, is critical to understand the TRUE structure of your drug product at the intended therapeutic conditions.
  • Microfluidic Modulation Spectroscopy provides a reliable platform with increased sensitive and higher resolution for secondary structure analysis of biotherapeutics.
  • MMS’s Automated walk away workflow makes it applicable for screening studies much earlier in the development process.

Recently investigators have begun to harness new technology such as microfluidic modulation spectroscopy (MMS) to reveal protein structural changes, as a solid understanding of structure and function is extremely important to the effectiveness of biotherapeutic drugs and scientist today are challenged in gathering a complete understanding with current tools During the biomanufacturing process, proteins such as antibodies, often undergo conformational changes that can alter their secondary structure, leading to critical variations in their overall function. These changes have been historically difficult to detect, as traditional analytical techniques are not great at detecting small differences in protein structure. MMS however, can detect these changes with great sensitivity and accuracy without the need for dilution or chemical alteration. Moreover, MMS offers detailed information on which structural motifs in the protein molecule are changing, providing more guidance to scientists in their efforts to develop more stable antibody molecules and formulations. Join us for this new BitesizeBio webinar where we will learn how MMS technology is making a significant impact toward understanding the structures of therapeutic antibodies and antibody drug conjugates.

Learning Objectives:

  • How Microfluidic Modulation Spectroscopy (MMS) can be used to understand the structures of therapeutic antibodies and antibody drug conjugates
  • Introduction to the AQS3™pro MMS system from RedShiftBio