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Patrick Miller-Rhodes

"Patrick is equal parts neuroscientist, writer, and extreme sports enthusiast. He is currently a Ph.D. candidate at the University of Rochester Medical Center, where he uses molecular biology techniques to study inflammation and neurodegeneration. To flesh out his scientific and medical writing portfolio, he pursues freelance writing opportunities when he’s not at the bench or off the grid.

Articles by Patrick Miller-Rhodes:

Multiplex CRISPR Gene Editing: What You Need to Know

If you need a multi-gene knockout or large-scale genomic modification, or want reduced off-target effects, then multiplex CRISPR is for you!

Image of amultiplex theatre to represent multiplex CRISPR experiments
27 May 2021 Genomics and Epigenetics

Microglial Cell Lines: The Ultimate Guide to Selection

Are needing to choose a microglial cell line? Want to ensure you are currently using the right one for your needs? Discover the different options available and how to choose.

image of microglia
02 Sep 2020 Cell Culture

What Does “N” Mean When Using Cell Lines?

If you’re confused about what N numbers mean for cell lines, you’re not alone. We explain it all and give you a guide on best practice.

Woman holding numebr 3 looking confused, representing how unclear n numbers for cell line experiments are
07 Jul 2020 Cells and Model Organisms

Five Ways to Modify Your siRNA for Improved RNAi 

Want to increase siRNA stability and efficiency? Read on to learn five chemical modifications that will help.

Five repairmen working denoting five modifications
04 Jun 2020 Chemistry for Biologists&DNA / RNA Manipulation and Analysis

How to Publish Negative Results (And Everything Else in Your Lab Notebook) 

Get your data out here! Learn about several venues that publish solid data, even if they don’t support your hypothesis or tell a story.

Man holding papers representing all work to be published
28 May 2020 Taming the Literature&Writing, Publishing and Presenting

How CRISPR Can Be Used to Detect Emerging Viral Pathogens

Discover two CRISPR-based viral diagnostic strategies, DETECTR and SHERLOCK.

A detective dressed like a detective to symbolize the DETECTR and SHERLOCK CRISPR methods for Viral diagnosis.
19 May 2020 Genomics and Epigenetics

CRISPR Nucleases: The Ultimate Guide To Selection

Confused about CRISPR nucleases? Read this guide to discover the various CRISPR nucleases available and what they are best suited for.

04 Feb 2020 Genomics and Epigenetics

CRISPR Multiplexing Strategies: What’s The Choice?

Although multiplex CRISPR gene editing can be accomplished by simply introducing more than one gRNA to your target cells, there are many alternative — and more efficient — ways of achieving this goal. This article discusses these alternative CRISPR multiplexing strategies and highlights their potential caveats. Not sure whether multiplex CRISPR gene editing is right…

28 Jan 2020 Genomics and Epigenetics

Faster Ligations: PEGing down the Secret

Overnight ligations are inconvenient — especially when they fail. Luckily, there’s a straightforward way to faster DNA ligations. This article highlights the secret ingredient to faster ligation reactions and offers some tips and caveats on its use. For a general overview of DNA ligations, see here and here. Buy a Quick Ligation Kit The most…

27 Nov 2019 DNA / RNA Manipulation and Analysis&New England Biolabs

How to Prevent False Results in Colony PCR

How to Prevent False Results in Colony PCR Colony PCR saves time and reduces costs by eliminating the need for plasmid purification. However, confounding results abound — but only if you fail to anticipate them. This article outlines the major perpetrators of false results and how to prevent them. For a more general overview of…

17 Oct 2019 PCR&PCR, qPCR and qRT-PCR

CRISPR-Based Activation (CRISPRa): A How-To Guide

CRISPRa allows you to activate or overexpress genes in a more endogenous manner. Find out the steps to getting started.

A light switch depiciting how CRISPRa allows you to swtich gene expression on
04 Oct 2019 Genomics and Epigenetics
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