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Sigma-Aldrich® Advanced Genomics

Unlocking research potential requires more than just cutting-edge technology. The Sigma-Aldrich® Advanced Genomics portfolio offers a comprehensive suite of tools that covers genome engineering from design through to analysis—at any scale.

Target a single gene or screen a whole genome of any species with our fully customizable products that come with expertise that extends from discovery to therapy. For your custom cell line engineering or lentiviral manufacturing needs, we partner with you to harness the power of CRISPR, RNAi and ZFN to unleash your full research potential.

ribonucleoprotein transformation

Why You Should Use Cas9 Ribonucleoprotein Transformation for CRISPR Genome Editing

Imagine directly creating a mutation at (almost) any site in your target genome instead of screening thousands or ...
whole genome sequencing

The Good, the Bad and the Expensive of Whole Genome Sequencing

Whole Genome Sequencing (WGS) is still very cutting edge, sequencing technology and while there are a lot of ...

Next Gen Sequencing Challenges

Next generation sequencing opened the doors to our genome. It gives massive amounts of information in a week ...

Codon Optimization 101

The intriguing thing about protein expression is that the combination of transfer RNAs (tRNAs) that translate the 3 ...
maxam-gilbert sequencing

Maxam-Gilbert Sequencing: What Was It, and Why It Isn’t Anymore

In the mid-1970s, two methods were developed for directly sequencing DNA: the Maxam-Gilbert sequencing (or chemical sequencing) method ...
nanopore sequencing

An Introduction to Nanopore Sequencing

DNA sequencing is the most powerful method to reveal genetic variations at the molecular level, leading to a ...

A Crash Course in CRISPR-Cas9 Editing in Drosophila

CRISPR-Cas9 has become a magic tool for molecular biologists, transforming genetic engineering from a once unbelievable dream into ...

How to Test the Efficiency of your sgRNA

To successfully edit your genome of interest, one critical step is to test the sgRNA you have designed. ...

Meeting the BioPython

The Biopython Project is an amazing initiative that helps scientists use Python for bioinformatics - and it’s exceptionally ...

Probability Theory and Molecular Barcodes

In biology, a molecular barcode is a characteristic DNA sequence used to distinguish and gather together similar items. ...
deep sequencing

Demystifying NGS: Depth Coverage and Deep Sequencing

NGS is not a three-headed monster. However, it can be a difficult concept to grasp—especially when you are ...
methylation

A Primer on Checking the Methylation State of the Genome

We all know that genes encode proteins that make up a living cell. However, the level and coordination ...
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