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Sigma-Aldrich® Advanced Genomics

Unlocking research potential requires more than just cutting-edge technology. The Sigma-Aldrich® Advanced Genomics portfolio offers a comprehensive suite of tools that covers genome engineering from design through to analysis—at any scale.

Target a single gene or screen a whole genome of any species with our fully customizable products that come with expertise that extends from discovery to therapy. For your custom cell line engineering or lentiviral manufacturing needs, we partner with you to harness the power of CRISPR, RNAi and ZFN to unleash your full research potential.

Activation

CRISPR-Based Activation (CRISPRa) of Genes: A How-To Guide

The purpose of this article is to walk you through the steps needed to overexpress genes using CRISPR/Cas9-based ...

CRISPR-Cas9 Genome Editing: Weighing the Pros and Cons

Genome editing is a hugely powerful tool which can help you to address a multitude of questions in ...
DNA barcoding

What’s that Organism? Using DNA Barcoding for Species Identification

In both the lab and field, it is important to know what species we are working with. While ...

How to Confirm Your CRISPR-cas9 Genome Editing Was Successful

You have sweated at the lab bench and in the cell culture suite for weeks (or more likely ...
gut microbiome

Kick-Start Your Gut Microbiome Study in Four Easy Steps

Today, the gut microbiome is garnering a large amount of media attention for its role in human health ...
DNA sequence

Studying the Epigenome by Next Generation Sequencing

The epigenome has been in the research spotlight, and for good reason. Not only has it been associated ...

Using dbSNP and ClinVar to Classify Gene Variants

As we discussed previously, the gaps in our understanding of the human genome make variant classification an extremely ...
Small child hiding in hallway, playing hide and seek

A Beginner’s Guide to Single-Cell RNA Sequencing

Since our early steps in Science we have been told that every cell in our body has the ...
K-mer

De Novo DNA Sequencing and the Special k-mer

The technology for DNA sequencing was developed back in 1977 thanks to Frederick Sanger. It took a bit ...
bioinformatics

How to Become a Bioinformatician

If you want to start a journey towards being a bioinformatician, you must first know the meaning of ...

A Crash Course in BLAST Searching

Simple BLAST searching is pretty straightforward to many of us. Just plug in your sequence, select the species ...

How to Use Ensembl to Classify Gene Variants

Even though our knowledge about genomes grows daily, and in huge leaps, we sometimes need to remind ourselves ...
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