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Harnessing the Power of Heterogeneity in Cryo-electron Microscopy

A major impediment in the determination of high resolution protein structures by single particle cryo-electron microscopy has been the presence of sample heterogeneity. Oftentimes, heterogeneity is due the dynamic nature of protein complexes, which can exist in multiple different conformational states in solution. Recent advancements in cryo-electron image processing have provided tools to accurately sort […]

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In FEI, Microscopy & Imaging 7th of June, 2017 Presented by: Richard Hite