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Louise Hughes

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Articles by Louise Hughes

Little biomolecules in a magnifying glass showing the types of things that can be viewed using electron microscopy

The 2 Main Electron Microscopy Techniques: SEM vs TEM

By Louise Hughes | April 6, 2022

Microscopy is a huge and active field. Sometimes, it’s easy to forget the basics. Read our biologists’ guide to electron microscopy techniques.

Researcher analyzing electrom microscopy images highlighting two methods of fixation for electron microscopy

Cryofixation and Chemical Fixation for Electron Microscopy

By Louise Hughes | April 23, 2019

Sample fixation for electron microscopy can be done using either chemical fixation or cryofixation. Discover the benefits and drawbacks of each of these methods.

Ultramicrotomy for Electron Microscopy

Ultramicrotomy for Electron Microscopy

By Louise Hughes | April 4, 2019

Ultramicrotomy is the process by which a sample is cut into very thin slices or “sections”, usually for imaging by transmission electron microscopy (TEM) or relatively new techniques using scanning electron microscopy (See Array tomography in three dimensional scanning electron microscopy for biology). This technique requires a bit of finesse, and this article will help…

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