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History of Molecular Biology

As a freshman biology major in undergrad, I was introduced to molecular biology with the following description: Molecular biology represents the intersection of genetics, biochemistry and cell biology. Some...
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The Invention of PCR

Few technical breakthroughs have changed the face of their field like the Polymerase Chain Reaction (PCR). Gene cloning, sequencing of complex genomes, DNA fingerprinting and DNA-based diagnostics are just some...
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Histone Methylation Determines Cell Fate

Gene expression is controlled at all sorts of levels in eukaryotic cells, and one of the hot areas is that of histone modifications and how they influence transcriptional accessibility on chromosomes -...
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10 Tips on Writing a Research Poster

Poster presentations are a great way to show off your hard work, especially if you are just starting out in research. They are much less stressful than oral presentations, but still provide great networking...
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Modeling Tertiary Structure

Predicting and modeling protein structure, making protein crystallography somewhat obsolete, has been an elusive science to date. Since Linus Pauling and others determined that the most favorable secondary...
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10 Links: Cell and Molecular Biology Podcasts

Podcasts are great. I listen to podcasts every day during my commute and find them a great way to pick up information, whether it's to learn about a new subject, brush up on something I have studied before or...
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How to: Keep your data organized

Talented, enthusiastic scientist required. Must have good organizational skills. Do you fit the bill? With the pace of molecular biology and biochemical research quickening year on year, the importance of...
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Solved: Heterologous Gene Expression Problems

When heterologous gene expression goes wrong it can be a real headache. Here's my checklist for the steps to take when you encounter problems with this dark art. 1. Check the construct by sequencing the...
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GFP Beach Scene

Just a bit of fun for a Friday... I've often thought that some of what we molecular biologists do with staining and things could easily pass for artwork, but I've never seen anything like this fantastic agar...
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Plasmid archiving at Addgene

Addgene is a non-profit plasmid repository that stores and distributes plasmids for academic labs. It's great if you work in an academic lab and they happen to have your plasmid - drop them an order and get...
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