Techniques / Genomics & Epigenetics

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Article

An Introduction To ChIP-seq

ChIP-seq is a wonderful technique that allows us to interrogate the physical binding interactions between protein and DNA using next-generation sequencing. In this article, I’ll give a brief review of ChIP...
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NxSeq™ Technology – Chimera-Free, High Efficiency Library Preparation for NGS Platforms

The efficiency of Next Generation Sequencing (NGS) depends on the quality of libraries used. Existing NGS sample preparation kits are not optimized for A-tailing, resulting in libraries that are not efficiently...
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Article

How DNA Microarrays are Built

Previously I introduced the DNA microarray technology and described the principle behind it: hybridization between the nucleic acid sequence from the biological samples being examined and a synthetic probe...
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Article

Introduction to DNA Microarrays

This is the first installment in the DNA microarray series where I will introduce the technology and explain the basics.
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Article

(Being) Exposed: The Secret Life of Dirt

Many of my current research projects are focused on the dirt that makes the world go round. No, not the kind that a paparazzi photographer or gossip columnist would be interested in. I am talking about soil....
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Article

Navigating the sea of human genetics, Part II

Avast, me hearties, I'm back with Part II of our exploration of the HuGE Navigator. To get up to speed, be sure to check out Part I. In Part II I'm going to go over the HuGEtools, which are used to mine the...
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Article

Genome Structure and Modularity

A minireview recently in Genomics caught my eye with the title Coexpression, coregulation, and cofunctionality of neighboring genes in eukaryotic genomes that sounded just like a passage that I recalled from...
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Article

Personal Genomes and Modern Eugenics

As genetic screening becomes increasingly advanced and personal genomes become more commonplace, the potential for genetic engineering and modern eugenics is becoming a reality. "Designer babies" may not be...
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Article

miRNAs Get Flipped

On a couple other blogs, a study published in Science by Joan Steitz1 is being called "One of the biggest findings of the year," and "If it turns out to be true, this finding just flipped the whole field on its...
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Article

Population Genetics Mechanisms on a Genomic Scale

Three papers from UC Davis have appeared on the PLoS journals in the past few days that bring together population genetics and genomic sequencing to address questions of importance to evolutionary biology. ...
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