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Extract HMW DNA for Long-Range Genomic Analysis with the New SageHLS Platform

Long-Range Genomic Analysis After a decade of DNA genomic sequencing being restricted to short reads, new technologies are making it possible for scientists to capture long-range genetic information that is...
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Size-Selection Is Essential for Cell-Free DNA Studies

Advances in using cell-free DNA (cfDNA) to glean clinically meaningful information for a patient have been stunning. For the most part, these research studies (or downstream diagnostic tests) isolate fetal DNA...
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Three Insights for Choosing the Best DNA Size Selection Method for Your Project

With so many methods for DNA size selection, it can be confusing to determine which is best for your project. Fortunately, academic researchers have evaluated many DNA size selection methods for a range of...
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In Genomics & Epigenetics, Sage Science
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How Does Automated Electrophoresis Perform DNA Size Selection?

Anytime lab processes get automated by a sophisticated scientific instrument, there can be a “black box” effect, leading users to wonder what’s going on in there. For DNA electrophoresis, it’s no...
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DNA Sizing Tutorial: When to Use Manual Gels, Beads, and More

There are several methods for size-selecting DNA fragments prior to sequencing. How do you choose which is best? Here’s a look at various options, plus considerations to help you determine when to use each...
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For Better NGS Assemblies, Use More Precise DNA Size Selection

It may not be intuitive that a sample preparation step like DNA size selection would have a significant impact on downstream data analysis, but NGS users have proven that it does. Indeed, the precision of your...
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The Art of Size Selection for Small RNAs

Size selection is a critical step in NGS pipelines, but may be most challenging for studies of small RNAs. The concept behind size selection is simple: separate a sheared DNA or cDNA sample by fragment size,...
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Whole-Sample Fractionation for NGS Pipelines with the SageELF

In many NGS workflows, you want more than just a single slice of your DNA sample — but most size selection methods make it difficult to salvage multiple bands or size ranges of DNA. This is especially...
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In Genomics & Epigenetics, Sage Science
Sponsored Education

For Long-Read Sequencers, Size Selection Is Key

It took scientists a little while to warm up to long-read sequencing, but now you couldn’t pry most of them away from their sequencers with a crowbar. Long reads — we’re talking 10,000 bases and more —...
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High-Throughput DNA Size Selection with the PippinHT

DNA size selection is a necessary but thankless task. Manual DNA sizing conjures images of postdocs slaving for hours over gels, trying to cut out specific bands with improbable accuracy. Automated DNA sizing,...
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In Genomics & Epigenetics, Sage Science