by Dan on November 7, 2007

Gene regulatory network (GRN) circuits are collections of DNA segments in a cell which interact with each other (indirectly through their RNA and protein expression products) and with other substances in the cell, thereby (read on...)

by Dan on November 6, 2007

Eukaryotic cells possess a surveillance mechanisms that identifies aberrantly processed mRNA precursors and prevents their flow to the cytoplasm by tethering them near the site of transcription. Termed post-translational (read on...)

by Dan on November 2, 2007

Site-specific recombinases have, for the past 20 years, been one of the most powerful tools in studying the functions of all sorts of genes. Most widely used as the Cre/lox-based system for inserting or deleting genes in mice, (read on...)

by Dan on November 1, 2007

Ubiquitin is a small protein, which can be attached to other cellular proteins - a post-translational modification called ubiquitination. Discoveries in the '80s illuminated ubiquitin as a label for degradation and recycling of (read on...)

by Dan on October 31, 2007

Perhaps the most fundamental aspect of migration of any kind is, how do you know which way to point yourself? Heck, this isn't just about migration, it's about how something is oriented in its immediate environment. For (read on...)

by Dan on October 29, 2007

Nature Precedings represents a step forward for disseminating experimental results in the internet age. Especially 'negative' results, that might not have gotten published otherwise, but is extremely helpful to other researchers (read on...)

by Dan on October 25, 2007

The Public Library of Science (PLoS) defines the issue of Open Access Publication as: An Open Access Publication[1] is one that meets the following two conditions: 1. The author(s) and copyright holder(s) grant(s) to all users a (read on...)

by Dan on October 23, 2007

Gene expression is controlled at all sorts of levels in eukaryotic cells, and one of the hot areas is that of histone modifications and how they influence transcriptional accessibility on chromosomes - epigenetic regulation, as (read on...)

by Dan on October 22, 2007

Predicting and modeling protein structure, making protein crystallography somewhat obsolete, has been an elusive science to date. Since Linus Pauling and others determined that the most favorable secondary structures are the (read on...)

by Nick on August 24, 2007

A Nature Structural & Molecular Biology article published by Singer et al has provided a fascinating insight into the kinetics of RNA polymerase II during transcription. (read on...)