Could Crowd-Funding Work In Science?

In times of financial crisis, as we are currently experiencing, some governments think that it’s OK, or even wise, to cut down on funding for scientific research. Even though we know better, we are […]

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Rubbing Your Microscope’s Eyes: A Guide to Optical Resolution

Ever wake up especially groggy in the morning, finding it takes a few minutes and a few eye rubs to be able to decipher the numbers on your alarm clock? Our eyes have the […]

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10 Uses for a PhD Thesis

Earning a PhD is something to be proud of. It represents years of hard work and an original contribution to science. And yet, the main product of this labor is a very large, rather […]

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Book Review: “The Double Helix”, by James Watson

Is it just me, or are there not many well-written scientific memoirs around? Even the words “scientific memoir” brings up an image of a long and boring book. There are a lot of good […]

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You’re Closer to the Clinic Than You Think: NGS and Clinical Trials

A decade or so ago, the phrase ‘translational research’ began making its rounds through laboratories- it was supposed to take molecular biology results and apply them directly to patients. It brought about things like […]

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The Advanced User’s Guide to Sequencing Alignment Software (Members Only Article)

Whether you’re employing sequencing gels, Sanger-based methods, or the latest in pyrosequencing or ion torrent technologies, obtaining, manipulating and analyzing your sequences has never been easier. Depending on what your goals are, you need […]

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Tissue Embedding and Sectioning: Something to Think About Whilst in the Bath.

In the same way that you should ‘Think Before You Fix’, the choice of embedding media should be dictated by your required end-point. The basic principle is that by processing tissue into an embedding […]

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The Beginners Guide to DNA Sequence Alignment

Fortunately, those of us who have learned how to sequence know that aligning sequences is a lot easier and less time consuming than creating them. Whether you’re employing sequencing gels, Sanger-based methods, or the […]

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Five Things You Might Not Know about LB

LB medium is a staple in virtually every lab. It’s commonly used to propagate E. coli, and as such will be used frequently by any lab that does cloning. Chances are, LB broth or […]

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A Short History of Sequencing Part 3: personal NGS, disposable sequencers and what the future holds.

Personalizing NGS Due to the relative ease of whole human genome sequencing, clinical researchers became interested in how they might use this technology to help their patients. There were, and still are, obstacles to […]

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