Getting the most out of your human DNA methylation studies

The field of epigenetics is exploding and given the strong links between epigenetic state and disease, the need to study markers like DNA methylation in humans is very relevant. This article outlines some of […]

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Land Of The Houyhnhnms: How NGS Turned The Genomic Clock Back 700,000 Years

Some 700,000 years ago, a male horse died alone in the Canadian Arctic.  Though he met his demise during a relatively warm period for the Yukon Territory, his corpse settled between thick layers of permafrost […]

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Book Review: Bad Pharma – Ben Goldacre

With a subtitle that says ‘How drug companies mislead doctors and harm patients’ you’re hardly expecting a comedy. Shockingly: on page 5 Ben Goldacre already dissolves all hopes that it might not be as […]

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Antigen Retrieval Techniques For Immunohistochemistry: Unmask That Antigen!

Just when you think that you've found the perfect fixative for your tissue, there’s something else to consider- your fixative may have just masked all the antigen sites your lovely new antibody was going […]

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The Luciferase Reporter Assay: How it works

The luciferase reporter assay is commonly used as a tool to study gene expression at the transcriptional level. It is widely used because it is convenient, relatively inexpensive, and gives quantitative measurements instantaneously. It […]

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What To Do When Whole Genome Sequencing Yields Unexpected Results: Is There A One-Size-Fits-All Answer?

Whole genome sequencing (WGS) is becoming increasingly common. Doctors now routinely order it for patients with puzzling diseases. The NHS (National Health Service in the UK) has declared that it will sequence 100,000 genomes over […]

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Fluorescent Tyramides In Histology: A Versatile Approach For Multiplex Molecular Tissue Probing.

If you are a researcher who is using fluorescent staining on your cells and tissue sections, you should seriously consider using tyramide reagents. Why? Well, because they can have exquisite sensitivity, are easy to […]

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Where to publish negative results

I met a final year PhD student once, who told me a sad story. His supervisor had a plausible idea that exercise reduces the chances of developing bowel cancer. To test the hypothesis, the […]

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8 more helpings of free PC Software for biological scientists

It's been while since we talked about free PC software for biologists. So we thought we'd treat you to 8 more ideas that can turn you PC in to a super-bio-research-enabling-machine….. 1. Silvernote Standard Electronic […]

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Breaking Up is (Not That) Hard to Do: Sonication for Cell Lysis

To answer some of the more interesting research questions, you often need to get a good look at what’s going on inside the cell. Whether you’re running a Western blot or measuring enzyme activity, […]

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