Beware The Bane of Batch Effects in NGS

 A promising study on using gene expression to develop personalized treatments for ovarian cancer A report of surprisingly high levels of differential gene expression among different ethnic groups. The announcement of previously unsuspected levels […]

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The different phases of PCR and why they are important

PCR (Polymerase Chain Reaction) is a biochemical technique developed by Kary Mullis in 1983 that is used to create large quantities of a sequence of DNA. Since this method of mass-producing DNA was first […]

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Red light/Green Light In Aseptic Technique: When Is The Flame OK?

My mom is a microbiologist and so I was a lot more informed about bugs than most kids. In fact, I probably gave more than one classmate nightmares with my talk of there being […]

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Come on in- the Water’s Lovely! A Look at Water Immersion Objectives

I’m guessing most people who have used a microscope will have come across oil immersion objectives- y’know- those ones which are covered in gunk and drip oil down into the sub-stage condenser?! If this […]

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Get Out of Western Blot Hell: An Intro to Mass Spectrometry.

  After you finish immunoprecipitating a protein or purifying a subcellular compartment, you need to identify what proteins you purified. You could attempt to identify your purified proteins the old fashioned (and slow!) way […]

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10 Useful Tips For Improving Your Sorting Experiments

After a very naïve start in flow cytometry thinking that published protocols will work without fault – needless to say, that did not work out in my favor – I realize now that following […]

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The Seven Deadly Sins of HPLC

Don't be a sinner!  Avoid  these sins and get the most from your HPLC run. 1.  Failing to maintain your HPLC column  There are a few cardinal sins when it comes to column maintenance: […]

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Apoptosis Gone Wrong: Cell Death’s Role in Disease

Like yin and yang, apoptosis has a duality.  While it is is a pathway used in the normal maintenance and development of tissues in healthy organisms it also had a dark side. As you […]

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Running You Through HPLC: How Does it Work?

Your advisor tells you that he wants you to use HPLC to analyze your compound. You know you’ve heard of this technique before, but you can’t remember what HPLC stands for, let alone how […]

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Cheat on your thermocycler with Loop-mediated Isothermal amplification (LAMP)

Is it time to breakup with your thermocycler? You and your thermocycler may be joined at the hip, but is it a love-hate relationship? Does it just eat up your time and money? Perhaps […]

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