"That Belongs To Me!": NGS Data and Security Part 2

In the first part of this article, we revisited progress in genetic testing, from mid-20th century blood-typing through to personalized medicine. The huge increase in personal health and genome data drag along security and ethical […]

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10 Easy ways to wreck your autoclave

You know how to wreck your microscope (yes, we’ve done that ourselves), and how to repurpose them when they’re old and obsolete. We’re busy brainstorming ways to destroy our centrifuge without annihilating the laboratory, […]

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How To Fix Adherent Cells For Microscopy And Imaging

Before you can image your adherent cells you need to fix them to your microscope slides. Luckily for you- this is fairly easy to do. Thanks to the fact that adherent cells are, well, […]

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How to identify protein motifs from protein sequences

Wouldn’t it be great to put your nucleotide sequence into a program and get back a 3D-structure of your protein and a full description of its functions? In theory, because the protein 3D-structure is […]

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"That Belongs To Me!": NGS Data and Security Part 1

Genetic testing has been with us for a century. It began with blood typing and tests for metabolic disorders like phenylketonuria (check the warning label on a can of Diet Coke), and by the […]

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Bad Science: Quacks, Hacks, and Big Pharma Flacks

A few summers ago, my son came home from day camp and reported that he saw a “bad magician.” Was the magician incompetent, I asked, or was he evil? The bad scientists Ben Goldacre […]

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Cell and Tissue Fixation 101- Top Tips For Protocol Optimization

You just can’t put raw tissue or cell samples on your slides and expect good histology results! Instead you must preserve or ‘fix’ your samples. Fixing ensures that your cell structures stay intact and […]

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Do science and copyright mix? (or: if you love your writing, set it free)

American academic and political activist Lawrence Lessig  argues that digital technologies allow all of us to change from passive consumers of culture to the its creators. Producing books, newspapers and movies in the 20th […]

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How to detect long non-coding RNA (lncRNA)

According to the central dogma of molecular biology, DNA is transcribed into RNA, that is translated to proteins. Inconveniently, the vast majority of the genome contains sequences that do not actually code for proteins. So, […]

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NGS and TRex: The Science Of Jurassic Park

The necessity to see negative scientific results in academic journals has recently drawn some attention. However, for the working experimentalist, it is still unthinkable that he or she would be able to publish meticulous […]

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