The future of PCR

After 30 years, what’s next for PCR? In the 80s, saying you were doing “PCR” was enough for everybody to know what kind of experiment you were performing. Today, the “PCR family” has gained […]

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Avoiding Plagiarism in Science

I remember when I first learned about plagiarism during my undergraduate course. The lecturers were so firm in telling us that if we got caught plagiarizing we would face serious repercussions and that all […]

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The Many Flavors of Widefield Microscopy

While confocal microscopy seems to have become pervasive in cell biology, widefield microscopy techniques still have a special and important place. This month on the Microscopy and Imaging Channel, we’re focusing on widefield microscopy […]

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How Bisulfite Pyrosequencing Works

Bisulfite pyrosequencing is becoming a routine technique in molecular biology labs as a method to precisely measure DNA methylation levels right down to the single base. The technique allows for detailed and high resolution […]

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How to train a junior colleague in the basics of PCR

PCR can be a tricky technique to master as it requires a lot of concentration and accuracy. It can be very easy for someone new to the technique to get overwhelmed and make mistakes. […]

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My Fifteen Favorite Things To Do In The Lab

What is my most favorite task to do in the lab? Good question; it’s difficult to pick just one, so here are (quite) a few of my favorite things: 1. Working in a team […]

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Catching Waves: What a Microscopist Ought to Know About Phase Contrast

Phase contrast microscopy is a light microscopy technique which is primarily used to visualise live cells. Using various filters and condensers, the image produced by phase contrast allows us to see greater detail in […]

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A Primer for Designing Degenerate Primers

For those of us who work with Mus musculus or Homo sapiens, to name a couple of species, a few clicks on UCSC Genome Bioinformatics Site or Ensembl gets you the full and precise […]

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Tower of Babel: Next Generation Sequencing Provides New Insights on Chromosome Construction

Biologists have long appreciated the complexity of genome organization, but until recently lacked the tools to discern the intricacies of this puzzle. Now, thanks to some handy cross-linking, careful amplification, and (of course!) next […]

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How to Deal With a Failed Experiment

Scientific success is often defined by how well your experiments progress and the results you produce. However, scientific research is driven by a curiosity about the unknown, and you cannot always be prepared for […]

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