Welcome to the Dark Side…Dark Field Microscopy That Is!

We all know that stars are easier to see against the dark background of the night than they are to see against the bright sky of day. Well did you also know that the […]

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Brahe’s Battles: The Outcome

What do science and rapping have in common?  Usually not much.  Unless you happen to be Tom McFadden that is, and then rapping becomes a tool for teaching kids about science. Tom McFadden is […]

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Gibson Assembly: an easy way of molecular cloning!

Every hard-core biologist knows designing the perfect construct can be a complex puzzle to solve. This challenge, if successful, can be extremely satisfying but can also drive you crazy for weeks. Luckily, Dr. Daniel […]

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How to Stay Organized in the Lab

Over the years, I have noticed that laboratory environments are just as fragile and sensitive as the experiments performed within. If permitted, the lab can deteriorate into a chaotic mess within only a few […]

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Light Through Crystals: What Exactly is Differential Interference Contrast Microscopy?

Although his name could fit in easily to the early 1980’s Hip-Hop Scene, Jerzy Nomarski (or ‘George’) was actually a Polish physicist with an interest in optical theory. Born in 1919, he eventually became […]

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Tips for Heating up Agar in the Microwave

One of our readers posted the following question to us and we decided to pass it along to everybody’s favorite microbiology expert, Aunt Yersinia: For one year I am working in different research laboratories, […]

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The future of PCR

After 30 years, what’s next for PCR? In the 80s, saying you were doing “PCR” was enough for everybody to know what kind of experiment you were performing. Today, the “PCR family” has gained […]

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Avoiding Plagiarism in Science

I remember when I first learned about plagiarism during my undergraduate course. The lecturers were so firm in telling us that if we got caught plagiarizing we would face serious repercussions and that all […]

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The Many Flavors of Widefield Microscopy

While confocal microscopy seems to have become pervasive in cell biology, widefield microscopy techniques still have a special and important place. This month on the Microscopy and Imaging Channel, we’re focusing on widefield microscopy […]

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How Bisulfite Pyrosequencing Works

Bisulfite pyrosequencing is becoming a routine technique in molecular biology labs as a method to precisely measure DNA methylation levels right down to the single base. The technique allows for detailed and high resolution […]

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