The Establishment of the Nobel Prize

Let’s play a game. I’ll say a word and you say what comes to your mind. Ready? Go! Cat… Kitchen… Doctor… Airplane… Nobel… I have no idea what you said when I said cat […]

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The Devil is in the Details: How to Setup a PCR Laboratory

There is a right way and a wrong way to set up a PCR laboratory. Because of PCR’s tremendous ability to amplify small quantities of DNA/RNA template, even the smallest of template contamination can […]

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An Easy Way to Start Using R in Your Research: Making Pretty Plots With ggplot

The thing that was most difficult for me as an R beginner was plotting graphs with error bars – there is no concise way to do this with base graphics. There are workarounds, often […]

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How Does BLAST Work?

More than a pun on the explosive growth of sequencing data, BLAST makes annotation and comparisons of similar sequences much easier. Created by a group at the U.S. National Center for Biotechnology Information in […]

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How to Check the Accuracy of Your Pipette

How much time do you spend thinking about the accuracy of your pipette? Probably not much. It’s one of those things that get brushed aside in the heat of experimentation. Pipetting accuracy though, is […]

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Type IIS Endonucleases – When Nature Lends a Hand With DNA Cloning

Good news lab workers! Always hated the tedious work of designing a cloning strategy? Or maybe always dreamed of pooling all the reactions in one tube, just to save time? Thanks to Mother Nature, […]

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Do-it-Yourself PCR

Currently Open Source principles are offering interesting tools for doing molecular biology at an incredibly low cost. One interesting example is OpenPCR (www.openPCR.org) a project developed in order to ensure that the basic technology to […]

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Getting started with Immunohistochemistry

What is immunohistochemistry… Immunohistochemistry (IHC) is a favorite tool amongst clinicians to help diagnose a range of diseases by identifying abnormal cells, such as those in cancer. In a nutshell, IHC uses antibodies to detect proteins (antigens) […]

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Spring Cleaning in the Lab – How not to Have Skeletons in your Lab Closet

Most of us hate cleaning and are often hard pressed to find time to clean our homes, never mind our laboratory space. However, an annual spring clean and maintenance of a regular cleaning rota/regime […]

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Biosafety in Flow Cytometry – To Be or Not to Be…

Biosafety is one of those things many scientists don't take seriously. I would guess, that like politics, there are 40% who believe biosafety is 'over-emphasized' and 40% who swear by biosafety. 20% are undecided. […]

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