The Lac Operon Explained

An operon is a functioning unit of genomic DNA that contains a group of genes controlled by a single promoter. Put simply, these genes share information needed to create the tools for a particular […]

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Heating up agar? Just add a cup of water and avoid the glitter and crumbs

It’s ironic how much folklore and superstition comes with being in science. “That’s a lucky pipette”, “playing Bach for your cells will help them grow”, “always make your own solutions”; we all have our […]

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Stereo (Dissecting) Microscopes 101

  Think a stereo microscope might be helpful? But you don’t know how to use one? Lucky for you I wrote this primer on stereo microscopes to help you figure out when and how […]

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Have I Got Good Protein Expression News for You

While the art of reading hand poured sequencing gels is forgotten as the next generation sequencers spit out genome after genome, protein expression still often requires sweat, tears and a lot of luck. I […]

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Taken for Granted: Position and Setup of Your Microscope

Although I say ‘taken for granted’, over the years of working in and managing microscope facilities, it quickly became clear that the position of the microscope, user position and set-up were aspects which were […]

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The History of PCR

As with some of the greatest discoveries in science, from penicillin to microwave ovens and play-doh, PCR was discovered serendipitously. Thanks to the work of many scientists, including Watson and Crick, Kornberg, Khorana, Klenow, […]

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How To Calculate The Number Of Molecules In Any Piece of DNA

It’s the dreaded topic, isn’t it? Calculating the number of molecules, the concentration of a solution, or working out serial dilutions were tasks that always filled me with dread as an undergrad. And to […]

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What Can NMR Do For You – Part Three

Welcome to part three of “What Can NMR Do For You” This is an ongoing series in which we describe how you can use NMR experiments to characterize your protein of interest. In part […]

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Beware The Bane of Batch Effects

A promising study on using gene expression to develop personalized treatments for ovarian cancer. A report of surprisingly high levels of differential gene expression among different ethnic groups. The announcement of previously unsuspected levels […]

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Overlap Extension PCR Cloning

If efficient cloning is what you are after, you must give Overlap Extension PCR Cloning a go! This restriction enzyme and T4 DNA ligase-free technique is faster, more reliable and easier to troubleshoot than […]

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