A Nature Structural & Molecular Biology article published by Singer et al has provided a fascinating insight into the kinetics of RNA polymerase II during transcription. Using a combination of extremely elegant fluorescent microscopy-based assays and computer modelling, the group have provided the first measurements of RNA polymerase II kinetics in living cells. Among their findings are that only 8% the RNA polymerase/promoter interactions lead to mRNA synthesis and that the elongation speed of the polymerase is much faster than previously thought. This is a remarkable piece of experimental design and is well worth reading.
I’ve always liked December, mainly because Christmas and my birthday fall in that month. But this December we are also celebrating moving into the Rolls-Royce of office spaces, at Nine, The BioQuarter in Edinburgh (photo above). This puts us right in the heart of the bioscience community in Edinburgh and turns the Scottish Centre for Regenerative […]
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