A Nature Structural & Molecular Biology article published by Singer et al has provided a fascinating insight into the kinetics of RNA polymerase II during transcription. Using a combination of extremely elegant fluorescent microscopy-based assays and computer modelling, the group have provided the first measurements of RNA polymerase II kinetics in living cells. Among their findings are that only 8% the RNA polymerase/promoter interactions lead to mRNA synthesis and that the elongation speed of the polymerase is much faster than previously thought. This is a remarkable piece of experimental design and is well worth reading.
It is with some regret, but much optimism for the future that we announce that BitesizeBio.com will cease to produce further articles and videos for biologists at the end of this month. We have been in business producing fantastic content to help scientists at the bench since 2007 and have grown our audience tantalisingly close to […]
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