Amid the political controversy and obstructions to conducting stem cell research, scientists this year managed to turn lead into gold… Genetically manipulating fibroblasts to become ESC(embryonic stem cell)-like sort of sounds like alchemy in a way, doesn’t it? The product of these papers, inducible pluripotent stem (iPS) cells, were created by transfecting four factors into fibroblasts, Oct3/4, Sox2, c-Myc, and Klf4, and they found that the epigenetic, morphological, and proliferative characteristics resembled those of embryonic stem cells.
The importance of these discoveries cannot be overstated. By ‘reprogramming’ regular cells into stem-like cells, and moving towards a technique that doesn’t inadvertently cause cancer, the expenses, difficulties, and controversies of regenerative therapy with stem cells are greatly reduced.
Yamanaka S. Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells. Cell Stem Cell (2007) 1:39-49. DOI:10.1016/j.stem.2007.05.012
When I started the third year of my PhD, I was advised to attend a course to learn to how to use Microsoft Word properly before I started writing. I laughed! Of course I knew how to use Word! Why on earth would I spend 3 hours at a course on something I already know […]
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