Amid the political controversy and obstructions to conducting stem cell research, scientists this year managed to turn lead into gold… Genetically manipulating fibroblasts to become ESC(embryonic stem cell)-like sort of sounds like alchemy in a way, doesn’t it? The product of these papers, inducible pluripotent stem (iPS) cells, were created by transfecting four factors into fibroblasts, Oct3/4, Sox2, c-Myc, and Klf4, and they found that the epigenetic, morphological, and proliferative characteristics resembled those of embryonic stem cells.
The importance of these discoveries cannot be overstated. By ‘reprogramming’ regular cells into stem-like cells, and moving towards a technique that doesn’t inadvertently cause cancer, the expenses, difficulties, and controversies of regenerative therapy with stem cells are greatly reduced.
Yamanaka S. Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells. Cell Stem Cell (2007) 1:39-49. DOI:10.1016/j.stem.2007.05.012
Is there anything more tedious than pH-ing a solution? Standing there adjusting the pH of your buffer, adding acid or alkali drop by drop until you get to the right pH… With pH-ing being so boring, it’s in our best interests to keep the equipment in good working order so that we needn’t fuss over […]
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