RNA Polymerase II Assayed in Living Cells
A Nature Structural & Molecular Biology article published by Singer et al has provided a fascinating insight into the kinetics of RNA polymerase II during transcription. Using a combination of extremely elegant fluorescent microscopy-based assays and computer modelling, the group have provided the first measurements of RNA polymerase II kinetics in living cells. Among their findings are that only 8% the RNA polymerase/promoter interactions lead to mRNA synthesis and that the elongation speed of the polymerase is much faster than previously thought. This is a remarkable piece of experimental design and is well worth reading.
About the Author
Nick Oswald
Nick is a molecular biologist-turned-publisher. After a PhD in Developmental Biology and an eclectic seven years in biotech he is now Editorial Manager of Neuroendocrinology and the founder and Editor-In-Chief of Bitesize Bio. You are welcome to connect with Nick on LinkedIn
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